Altered function and histology in guinea pigs after inhalation of diesel exhaust

Journal Article · Fri Aug 01 04:00:00 EDT 1980 · Environ. Res.; (United States)

DOI:https://doi.org/10.1016/0013-9351(80)90141-3· OSTI ID:6783434

Wiester, M J; Iltis, R; Moore, E

Health effects of inhaled diesel engine exhaust were evaluated in infant guinea pigs following 4 and 8 weeks of exposure. Animals were exposed to 1 part exhaust diluted by 13 parts clean air for 20 hr/day, 7 days/week. Lung function, electrocardiogram, growth rate, and histopathology were assessed following exposure. After 4 weeks, animals exposed to irradiated exhaust showed a 35% increase in pulmonary air flow resistance, and a small but significant decrease in heart rate. Necropsy, after 8 weeks, showed exhaust exposed animals to have discoloration of the lungs and increased lung to body weight ratios. Microscopic examination of the lungs from these animals revealed black particulate material in the cytoplasm of alveolar macrophages and in draining lymph nodes.

• Research Organization: HERL, US Environmental Protection Agency, Cincinnati, OH
• OSTI ID: 6783434
• Journal Information: Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 22:2; ISSN ENVRA
• Country of Publication: United States
• Language: English

Related Subjects

560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
ANIMALS
BIOLOGICAL EFFECTS
BODY
COLLOIDS
COMPARATIVE EVALUATIONS
DIESEL ENGINES
DIESEL FUELS
DISPERSIONS
ENGINES
EXHAUST GASES
FLUIDS
GASEOUS WASTES
GASES
GROWTH
GUINEA PIGS
HEAT ENGINES
HISTOLOGICAL TECHNIQUES
INHALATION
INJURIES
INTAKE
INTERNAL COMBUSTION ENGINES
LUNGS
MAMMALS
ORGANS
PETROLEUM PRODUCTS
RESPIRATORY SYSTEM
RODENTS
SOLS
VERTEBRATES
WASTES