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Human oral and inhalation exposures to lead: summary of Kehoe balance experiments

Journal Article · · J. Toxicol. Environ. Health; (United States)

Ingestion experiments involved daily supplements of 300, 1000, 2000, and 3000 ..mu..g Pb per day. Except for subject SW, who received the 300 ..mu..g supplementation, all subjects experienced increased Pb in the blood, urine, feces, and body burden proportional to the ingested Pb. For SW, blood and urine Pb did not increase even though body and fecal Pb did. Overall, the feces, blood, urine, and balance increased by 0.83 ..mu..g/d, 0.017 ..mu..g per 100 g, 0.045 ..mu..g/d, and 0.133 ..mu..g/d for each increase of 1 ..mu..g Pb in the diet. Inhalation exposure experiments involved chamber concentrations of 10, 20, 75, and 150 ..mu..g/m/sup 3/ for varying exposure times. Overall chamber exposure rates ranged from 0.6 to 35.9 ..mu..g/m/sup 3/, averaged over the entire exposure period. The influence of natural variability of dietary Pb permeated all inhalation experimental periods and tended to override the responses of blood, urinary, and fecal Pb at adjusted exposure rates below 10 ..mu..g/m/sup 3/ (below chamber concentrations of 75 ..mu..g/m/sup 3/). Overall, the blood, urine, and feces increased by 0.57 ..mu..g per 100 g, 1.41 ..mu..g/d and 1.47 ..mu..g/d for each increase of 1 ..mu..g/lm/sup 3/ Pb in the air. All subjects who experienced obvious increases in body Pb during their exposure periods showed obvious and prompt body Pb washout during postexposure periods.

Research Organization:
Univ. of Cincinnati, OH
OSTI ID:
5760320
Journal Information:
J. Toxicol. Environ. Health; (United States), Journal Name: J. Toxicol. Environ. Health; (United States) Vol. 8:3; ISSN JTEHD
Country of Publication:
United States
Language:
English

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Related Subjects

560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BLOOD
BODY FLUIDS
CHEMICAL ANALYSIS
DIET
ELEMENTS
FECES
INGESTION
INHALATION
INTAKE
LEAD
MATERIALS
METALS
QUANTITATIVE CHEMICAL ANALYSIS
URINE
WASTES