Human oral and inhalation exposures to lead: summary of Kehoe balance experiments

Journal Article · Tue Sep 01 00:00:00 EDT 1981 · J. Toxicol. Environ. Health; (United States)

DOI:https://doi.org/10.1080/15287398109530075· OSTI ID:5760320

Gross, S B

Ingestion experiments involved daily supplements of 300, 1000, 2000, and 3000 ..mu..g Pb per day. Except for subject SW, who received the 300 ..mu..g supplementation, all subjects experienced increased Pb in the blood, urine, feces, and body burden proportional to the ingested Pb. For SW, blood and urine Pb did not increase even though body and fecal Pb did. Overall, the feces, blood, urine, and balance increased by 0.83 ..mu..g/d, 0.017 ..mu..g per 100 g, 0.045 ..mu..g/d, and 0.133 ..mu..g/d for each increase of 1 ..mu..g Pb in the diet. Inhalation exposure experiments involved chamber concentrations of 10, 20, 75, and 150 ..mu..g/m/sup 3/ for varying exposure times. Overall chamber exposure rates ranged from 0.6 to 35.9 ..mu..g/m/sup 3/, averaged over the entire exposure period. The influence of natural variability of dietary Pb permeated all inhalation experimental periods and tended to override the responses of blood, urinary, and fecal Pb at adjusted exposure rates below 10 ..mu..g/m/sup 3/ (below chamber concentrations of 75 ..mu..g/m/sup 3/). Overall, the blood, urine, and feces increased by 0.57 ..mu..g per 100 g, 1.41 ..mu..g/d and 1.47 ..mu..g/d for each increase of 1 ..mu..g/lm/sup 3/ Pb in the air. All subjects who experienced obvious increases in body Pb during their exposure periods showed obvious and prompt body Pb washout during postexposure periods.

• Research Organization: Univ. of Cincinnati, OH
• OSTI ID: 5760320
• Journal Information: J. Toxicol. Environ. Health; (United States), Vol. 8:3
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
LEAD
BIOLOGICAL EFFECTS
BLOOD
DIET
FECES
INGESTION
INHALATION
QUANTITATIVE CHEMICAL ANALYSIS
URINE
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY FLUIDS
CHEMICAL ANALYSIS
ELEMENTS
INTAKE
MATERIALS
METALS
WASTES
560306* - Chemicals Metabolism & Toxicology- Man- (-1987)