Long-term clearance of inhaled diesel exhaust particles in rodents

Journal Article · · J. Toxicol. Environ. Health; (United States)

DOI:https://doi.org/10.1080/15287398309530471· OSTI ID:6846781

Lee, P S; Chan, T L; Hering, W E

The fate of inhaled diesel exhaust particles was studied in male Fischer 344 rats and Hartley guinea pigs using radioactive diesel particles, tagged in the insoluble particulate core with /sup 14/C and generated from a single-cylinder diesel engine. The potential artifact of increased radioactivity due to the absorption of /sup 14/CO/sub 2/ in the blood was minimized by passing the exhaust through a diffusion scrubber prior to its dilution and introduction into a nose-only exposure chamber. Disappearance of the inhaled /sup 14/CO/sub 2/ from blood through the expired air and urine was rapid, indicating that a correction for the increased radioactivity was necessary only for tissue samples generated during the first day after the exposure. An atomic absorption spectrophotometric method was developed to determine the amount of blood and, thus, its contribution of /sup 14/CO/sub 2/ activity in excised organs and tissues. Fischer rats exposed to diluted diesel exhaust at 2 particulate concentrations with similar total inhaled dose (7 mg/m/sup 3/ for 45 min, and 2 mg/m/sup 3/ for 140 min) had comparable deposition efficiencies and showed no significant difference in particle clearance for data measured up to 1 yr after the exposure. Long-term retention of inhaled diesel particles in Fischer rats, measured up to 330 d after the exposure, was analyzed as 3 clearance phases with half-times of 1 d, 6 d, and 80 d, respectively. In contrast, very little clearance was observed in guinea pigs between d 10 and d 432 after the exposure, and only the early clearance phase can be represented by a single exponential curve with a half-time of 1-2 d.

• Research Organization: General Motors Research Lab., Warren, MI
• OSTI ID: 6846781
• Journal Information: J. Toxicol. Environ. Health; (United States), Journal Name: J. Toxicol. Environ. Health; (United States) Vol. 12:4-6; ISSN JTEHD
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BLOOD
BODY FLUIDS
BREATH
CARBON 14 COMPOUNDS
CARBON COMPOUNDS
CARBON DIOXIDE
CARBON OXIDES
CHALCOGENIDES
CLEARANCE
COMPARATIVE EVALUATIONS
DIESEL ENGINES
DISTRIBUTION
ENGINES
EXHAUST GASES
EXPOSURE CHAMBERS
FLUIDS
FUNCTIONS
GASEOUS WASTES
GASES
GUINEA PIGS
HEAT ENGINES
INHALATION
INTAKE
INTERNAL COMBUSTION ENGINES
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
MATERIALS
OXIDES
OXYGEN COMPOUNDS
PARTICLES
PARTICULATES
RATS
RETENTION FUNCTIONS
RODENTS
SPECTROPHOTOMETRY
TIME DEPENDENCE
TISSUE DISTRIBUTION
TRACER TECHNIQUES
URINE
VERTEBRATES
WASTES