Pulmonary retention of inhaled diesel particles after prolonged exposures to diesel exhaust
Journal Article
·
· Fundam. Appl. Toxicol.; (United States)
The effect of continuous exposure to diluted diesel exhaust on the pulmonary retention of inhaled diesel particles was studied in male Fischer 344 rats. Test animals were first exposed to clean air or diluted diesel exhaust in exposure chambers at nominal particulate concentrations of 250 micrograms/m/sup 3/ or 6 mg/m/sup 3/ for 20 hr/day, 7 days/week, for periods lasting from 7 to 112 days, followed by a nose-only exposure to /sup 14/C-tagged diesel particles for 45 min. At preselected time intervals after the radioactive exposure, the /sup 14/C-activities in the lungs of groups of four animals were measured to determine the clearance of the /sup 14/C-diesel particles up to 1 year. The pulmonary retention of the radioactive diesel particles was greater in animals which had been preexposed to diesel exhaust. The slower alveolar clearance of particle-laden macrophages and leukocytes can be described by a normal biphasic clearance model.
- Research Organization:
- General Motors Technical Center, Warren, MI
- OSTI ID:
- 5776208
- Journal Information:
- Fundam. Appl. Toxicol.; (United States), Journal Name: Fundam. Appl. Toxicol.; (United States) Vol. 4:4; ISSN FAATD
- Country of Publication:
- United States
- Language:
- English
Similar Records
Lung clearance of inhaled particles after exposure to carbon black generated from a resuspension system
Long-term clearance of inhaled diesel exhaust particles in rodents
Inhaled particle retention in rats receiving low exposures of diesel exhaust
Journal Article
·
Sat Aug 01 00:00:00 EDT 1987
· Environ. Res.; (United States)
·
OSTI ID:6184067
Long-term clearance of inhaled diesel exhaust particles in rodents
Journal Article
·
· J. Toxicol. Environ. Health; (United States)
·
OSTI ID:6846781
Inhaled particle retention in rats receiving low exposures of diesel exhaust
Journal Article
·
Sun Dec 31 23:00:00 EST 1989
· Journal of Toxicology and Environmental Health; (USA)
·
OSTI ID:6905356
Related Subjects
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CARBON 14 COMPOUNDS
CHRONIC EXPOSURE
CLEARANCE
CONNECTIVE TISSUE CELLS
DIESEL ENGINES
ENGINES
EXCRETION
EXHAUST GASES
FLUIDS
FUNCTIONS
GASEOUS WASTES
GASES
HEAT ENGINES
INHALATION
INTAKE
INTERNAL COMBUSTION ENGINES
LABELLED COMPOUNDS
LEUKOCYTES
LUNG CLEARANCE
LUNGS
MACROPHAGES
MAMMALS
MATERIALS
ORGANS
PARTICLES
PARTICULATES
PHAGOCYTES
RATS
RESPIRATORY SYSTEM
RETENTION FUNCTIONS
RODENTS
SOMATIC CELLS
VERTEBRATES
WASTES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CARBON 14 COMPOUNDS
CHRONIC EXPOSURE
CLEARANCE
CONNECTIVE TISSUE CELLS
DIESEL ENGINES
ENGINES
EXCRETION
EXHAUST GASES
FLUIDS
FUNCTIONS
GASEOUS WASTES
GASES
HEAT ENGINES
INHALATION
INTAKE
INTERNAL COMBUSTION ENGINES
LABELLED COMPOUNDS
LEUKOCYTES
LUNG CLEARANCE
LUNGS
MACROPHAGES
MAMMALS
MATERIALS
ORGANS
PARTICLES
PARTICULATES
PHAGOCYTES
RATS
RESPIRATORY SYSTEM
RETENTION FUNCTIONS
RODENTS
SOMATIC CELLS
VERTEBRATES
WASTES