Lung clearance of inhaled particles after exposure to carbon black generated from a resuspension system

Journal Article · Sat Aug 01 04:00:00 EDT 1987 · Environ. Res.; (United States)

DOI:https://doi.org/10.1016/S0013-9351(87)80037-3· OSTI ID:6184067

Lee, P S; Gorski, R A; Hering, W E; Chan, T L

A system to resuspend carbon black particles for providing submicron aerosols for inhalation exposure studies has been developed. The effect of continuous exposure to carbonaceous material (as a surrogate for the carbonaceous particles in diesel exhaust) on the pulmonary clearance of inhaled diesel tracer particles was studied in male Fischer 344 rats. Submicron carbon black particles with a mass median aerodynamic diameter (MMAD) of 0.22 micron and a size distribution similar to that of exhaust particles from a GM 5.7-liter diesel engine were successfully generated and administered to test animals at a nominal concentration of 6 mg/m3 for 20 hr/day, 7 days/week, for periods lasting 1 to 11 weeks. Immediately after the carbon black exposure, test animals were administered /sup 14/C-tagged diesel particles for 45 min in a nose-only chamber. The pulmonary retention of inhaled radioactive tracer particles was determined at preselected time intervals. Based upon the data collected up to 1 year postexposure, prolonged exposure to carbon black particles exhibits a similar inhibitory effect on pulmonary clearance as does prolonged exposure to diesel exhaust with a comparable particulate dose. This observation indicates that the excessive accumulation of carbonaceous material may be the predominant factor affecting lung clearance.

• Research Organization: General Motors Technical Center, Warren, MI
• OSTI ID: 6184067
• Journal Information: Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 43:2; ISSN ENVRA
• Country of Publication: United States
• Language: English

Related Subjects

02 PETROLEUM
020600* -- Petroleum-- Health & Safety
550501 -- Metabolism-- Tracer Techniques
560300 -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
ANIMALS
CARBON
CARBON 14 COMPOUNDS
CARBON BLACK
CLEARANCE
COLLOIDS
DIESEL ENGINES
DISPERSIONS
ELEMENTS
ENGINES
EXCRETION
EXHAUST GASES
FLUIDS
GASEOUS WASTES
GASES
HEAT ENGINES
INHALATION
INTAKE
INTERNAL COMBUSTION ENGINES
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
LUNG CLEARANCE
MAMMALS
METABOLISM
NONMETALS
PARTICLE SIZE
PARTICLES
PARTICULATES
RATS
RETENTION
RODENTS
SIZE
SOLS
TRACER TECHNIQUES
VERTEBRATES
WASTES