Polychlorinated biphenyls and dibenzofurans in patients with yusho and their toxicological significance: a review
The rice oil ingested by the patients with Yusho and their blood, liver, and adipose tissue were analyzed for individual congeners of polychlorinated biphenyls (PCBs) and polychlorinated dibenzofurans (PCDFs). The individual congeners identified were examined for accumulation in the liver of monkeys and rats, inducing activities of benzo(a)pyrene 3-hydroxylase, benzphetamine demethylase, and DT-diaphorase in rats, and gravimetric changes of the thymus and liver in rats. Among the six PCB congeners detected in Yusho patients, 2,3,4,5,3',4'-hexa-CB seems to be the compound most related to Yusho judging from its strong enzyme-inducing activities in the liver and the thymus atrophy and liver hypertrophy caused by feeding it to rats. PCDF congeners identified in the patients' tissues showed a stronger toxicity in rats than these PCBs, exhibiting stronger enzyme induction activities and gravimetric changes of the tissues. These PCDF congeners, especially 2,3,4,7,8-penta-CDF, were also very accumulative in the liver. Therefore, they are considered as the most important etiologic agents for the current symptoms and signs of Yusho patients.
- Research Organization:
- Daiichi College of Pharmaceutical Sciences, Fukuoka, Japan
- OSTI ID:
- 6846641
- Journal Information:
- Am. J. Ind. Med.; (United States), Vol. 5:1-2
- Country of Publication:
- United States
- Language:
- English
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ADIPOSE TISSUE
CHEMICAL ANALYSIS
BLOOD
CHLORINATED AROMATIC HYDROCARBONS
TOXICITY
FURANS
LIVER
VEGETABLE OILS
BIOLOGICAL LOCALIZATION
METABOLIC ACTIVATION
MONKEYS
PATIENTS
RATS
ANIMAL TISSUES
ANIMALS
AROMATICS
BIOLOGICAL MATERIALS
BODY
BODY FLUIDS
CONNECTIVE TISSUE
DIGESTIVE SYSTEM
GLANDS
HALOGENATED AROMATIC HYDROCARBONS
HETEROCYCLIC COMPOUNDS
MAMMALS
MATERIALS
OILS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANS
OTHER ORGANIC COMPOUNDS
PRIMATES
RODENTS
TISSUES
VERTEBRATES
560306* - Chemicals Metabolism & Toxicology- Man- (-1987)
560305 - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)