Polychlorinated biphenyls and dibenzofurans in patients with yusho and their toxicological significance: a review

Journal Article · Sat Dec 31 23:00:00 EST 1983 · Am. J. Ind. Med.; (United States)

DOI:https://doi.org/10.1002/ajim.4700050105· OSTI ID:6846641

Masuda, Y; Yoshimura, H

The rice oil ingested by the patients with Yusho and their blood, liver, and adipose tissue were analyzed for individual congeners of polychlorinated biphenyls (PCBs) and polychlorinated dibenzofurans (PCDFs). The individual congeners identified were examined for accumulation in the liver of monkeys and rats, inducing activities of benzo(a)pyrene 3-hydroxylase, benzphetamine demethylase, and DT-diaphorase in rats, and gravimetric changes of the thymus and liver in rats. Among the six PCB congeners detected in Yusho patients, 2,3,4,5,3',4'-hexa-CB seems to be the compound most related to Yusho judging from its strong enzyme-inducing activities in the liver and the thymus atrophy and liver hypertrophy caused by feeding it to rats. PCDF congeners identified in the patients' tissues showed a stronger toxicity in rats than these PCBs, exhibiting stronger enzyme induction activities and gravimetric changes of the tissues. These PCDF congeners, especially 2,3,4,7,8-penta-CDF, were also very accumulative in the liver. Therefore, they are considered as the most important etiologic agents for the current symptoms and signs of Yusho patients.

• Research Organization: Daiichi College of Pharmaceutical Sciences, Fukuoka, Japan
• OSTI ID: 6846641
• Journal Information: Am. J. Ind. Med.; (United States), Journal Name: Am. J. Ind. Med.; (United States) Vol. 5:1-2; ISSN AJIMD
• Country of Publication: United States
• Language: English

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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADIPOSE TISSUE
ANIMAL TISSUES
ANIMALS
AROMATICS
BIOLOGICAL LOCALIZATION
BIOLOGICAL MATERIALS
BLOOD
BODY
BODY FLUIDS
CHEMICAL ANALYSIS
CHLORINATED AROMATIC HYDROCARBONS
CONNECTIVE TISSUE
DIGESTIVE SYSTEM
FURANS
GLANDS
HALOGENATED AROMATIC HYDROCARBONS
HETEROCYCLIC COMPOUNDS
LIVER
MAMMALS
MATERIALS
METABOLIC ACTIVATION
MONKEYS
OILS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANS
OTHER ORGANIC COMPOUNDS
PATIENTS
PRIMATES
RATS
RODENTS
TISSUES
TOXICITY
VEGETABLE OILS
VERTEBRATES