Biological effect of PCBs, PCQs and PCDFs present in the oil causing Yusho and Yu-Cheng

Journal Article · Thu Jan 31 23:00:00 EST 1985 · Environ. Health Perspect.; (United States)

DOI:https://doi.org/10.2307/3429878· OSTI ID:5414652

Kunita, N; Hori, S; Obana, H; Otake, T; Nishimura, H; Kashimoto, T; Ikegami, N

Male Sprague-Dawley rats were daily given orally for 22 days a regimen consisting of polychlorinated biphenyls (PCBs), 1 mg/day; polychlorinated quaterphenyls (PCQs), 1 mg/day; polychlorinated dibenzofurans (PCDFs), 10 ..mu..g/day; or a mixture of PCBs, PCQs and PCDFs (Mix-1, 1 mg + 1 mg + 10 ..mu..g/day). Female cynomolgus monkeys were daily administered PCBs (5 mg), PCQs (5 mg) or a mixture (Mix-2) containing 5 mg PCBs + 20 ..mu..g PCDFs for 20 weeks. The PCB-treated rats and monkeys showed hepatic hypertrophy, immunosuppression and increased drug-metabolizing enzyme activities in hepatic microsomes, but were devoid of the dermal symptoms characteristic of Yusho. PCQs caused an increase in drug-metabolizing enzyme activities in hepatic microsomes and immunosuppression in monkeys, but these effects were much smaller than those found with PCBs treatment. On the other hand, treatment with PCDF or Mix-1 or Mix-2 caused hypertrophy of the liver, immunosuppression, increase in drug-metabolizing enzyme activities of hepatic microsome to much greater extent than observed with PCBs. In addition PCDFs and the mixtures containing PCDFs caused weight loss and thymic atrophy. PCDFs and Mix-2-treated monkeys showed the dermal symptoms that are characteristic of Yusho patients but were not observed in monkeys treated with PCBs and PCQs alone. These results suggest that PCDFs are the primary causative agent of Yusho.

• Research Organization: National Osaka Hospital, Japan
• OSTI ID: 5414652
• Journal Information: Environ. Health Perspect.; (United States), Journal Name: Environ. Health Perspect.; (United States) Vol. 59; ISSN EVHPA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AROMATICS
ASIA
ATROPHY
BENZOFURANS
BIOLOGICAL EFFECTS
BODY
CHLORINATED AROMATIC HYDROCARBONS
DIGESTIVE SYSTEM
ENZYME ACTIVITY
ETIOLOGY
FURANS
GLANDS
HALOGENATED AROMATIC HYDROCARBONS
HETEROCYCLIC COMPOUNDS
HYDROCARBONS
HYPERTROPHY
IMMUNOSUPPRESSION
ISLANDS
JAPAN
LIVER
LYMPHATIC SYSTEM
MAMMALS
MONKEYS
OILS
ORAL ADMINISTRATION
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANS
OTHER ORGANIC COMPOUNDS
PATHOLOGICAL CHANGES
PATIENTS
PRIMATES
QUATERPHENYLS
RATS
RODENTS
SKIN
TAIWAN
THYMUS
VEGETABLE OILS
VERTEBRATES
WEIGHT