PCB and PCDF congeners in the blood and tissues of Yusho and Yu-Cheng patients

Journal Article · Fri Feb 01 00:00:00 EST 1985 · Environ. Health Perspect.; (United States)

DOI:https://doi.org/10.2307/3429874· OSTI ID:5384240

Masuda, Y; Kuroki, H; Haraguchi, K; Nagayama, J

Polychlorinated biphenyl (PCB) poisonings occurred in western Japan, where it is called Yusho, in 1968, and in central Taiwan, where it is called Yu-Cheng, in 1979. The average concentrations of PCBs in the adipose tissue, liver and blood of Yusho patients and in the blood of Yu-Cheng patients were 1.9 ppm, 0.08 ppm, 6.7 ppb and 99 ppb, respectively. Seven PCB congeners, such as 2,4,5,3',4'-pentachloro-, 2,3,4,3',4'-pentachloro-, 2,4,5,2',4',5'-hexachloro-, 2,3,4,2',4',5'-hexachloro-, 2,3,4,5,3',4'-hexachloro-, 2,3,4,5,2',4',5'- heptachloro- and 2,3,4,5,2',3',4'-heptachloro biphenyls were identified in the blood and tissues of patients with Yusho and Yu-Cheng and controls. The concentration of 2,3,4,5,3',4'-hexachlorobiphenyl was comparatively higher in the patients than in controls. The concentrations of polychlorinated dibenzofurans (PCDFs) in the adipose tissue and liver of Yusho patients were 6 to 13 ppb and 3 to 25 ppb, respectively, while no PCDFs were detected in the controls. Major PCDF congeners identified in the tissues and blood of Yusho and Yu-Cheng patients were the 2,3,6,8-tetrachloro-, 2,3,7,8-tetrachloro-, 1,2,4,7,8-pentachloro-, 2,3,4,7,8-pentachloro- and 1,2,3,4,7,8-hexachlorodibenzofurans (DFs), of which the 2,3,4,7,8-pentachloro compound was predominant. Some of the major peaks of the PCB methylthio and methylsulfone derivatives were identical in gas chromatographic retention times with those of 4-methylthio- and 4-methylsulfone-2,5-2',5'-tetrachlorobiphenyl PCDFs, especially 2,3,4,7,8-pentachloro DF, appear to be mainly responsible in the poisonings.

• OSTI ID: 5384240
• Journal Information: Environ. Health Perspect.; (United States), Vol. 59
• Country of Publication: United States
• Language: English

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