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PCB and PCDF congeners in the blood and tissues of Yusho and Yu-Cheng patients

Journal Article · · Environ. Health Perspect.; (United States)
DOI:https://doi.org/10.2307/3429874· OSTI ID:5384240
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Polychlorinated biphenyl (PCB) poisonings occurred in western Japan, where it is called Yusho, in 1968, and in central Taiwan, where it is called Yu-Cheng, in 1979. The average concentrations of PCBs in the adipose tissue, liver and blood of Yusho patients and in the blood of Yu-Cheng patients were 1.9 ppm, 0.08 ppm, 6.7 ppb and 99 ppb, respectively. Seven PCB congeners, such as 2,4,5,3',4'-pentachloro-, 2,3,4,3',4'-pentachloro-, 2,4,5,2',4',5'-hexachloro-, 2,3,4,2',4',5'-hexachloro-, 2,3,4,5,3',4'-hexachloro-, 2,3,4,5,2',4',5'- heptachloro- and 2,3,4,5,2',3',4'-heptachloro biphenyls were identified in the blood and tissues of patients with Yusho and Yu-Cheng and controls. The concentration of 2,3,4,5,3',4'-hexachlorobiphenyl was comparatively higher in the patients than in controls. The concentrations of polychlorinated dibenzofurans (PCDFs) in the adipose tissue and liver of Yusho patients were 6 to 13 ppb and 3 to 25 ppb, respectively, while no PCDFs were detected in the controls. Major PCDF congeners identified in the tissues and blood of Yusho and Yu-Cheng patients were the 2,3,6,8-tetrachloro-, 2,3,7,8-tetrachloro-, 1,2,4,7,8-pentachloro-, 2,3,4,7,8-pentachloro- and 1,2,3,4,7,8-hexachlorodibenzofurans (DFs), of which the 2,3,4,7,8-pentachloro compound was predominant. Some of the major peaks of the PCB methylthio and methylsulfone derivatives were identical in gas chromatographic retention times with those of 4-methylthio- and 4-methylsulfone-2,5-2',5'-tetrachlorobiphenyl PCDFs, especially 2,3,4,7,8-pentachloro DF, appear to be mainly responsible in the poisonings.

OSTI ID:
5384240
Journal Information:
Environ. Health Perspect.; (United States), Journal Name: Environ. Health Perspect.; (United States) Vol. 59; ISSN EVHPA
Country of Publication:
United States
Language:
English

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Related Subjects

560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADIPOSE TISSUE
ANIMAL TISSUES
AROMATICS
ASIA
BENZOFURANS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CHEMISTRY
BODY
BODY FLUIDS
CHLORINATED AROMATIC HYDROCARBONS
CONNECTIVE TISSUE
DIGESTIVE SYSTEM
DISTRIBUTION
ETIOLOGY
FURANS
GLANDS
HALOGENATED AROMATIC HYDROCARBONS
HETEROCYCLIC COMPOUNDS
INGESTION
INTAKE
ISLANDS
JAPAN
LIVER
MATERIALS
METABOLITES
OILS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANS
OTHER ORGANIC COMPOUNDS
SYMPTOMS
TAIWAN
TISSUE DISTRIBUTION
TISSUES
VEGETABLE OILS