Mammary gland tumors in irradiated and untreated guinea pigs

Journal Article · Wed Jan 01 04:00:00 EST 1986 · Toxicol. Pathol.; (United States)

DOI:https://doi.org/10.1177/019262338601400301· OSTI ID:6840840

Hoch-Ligeti, C; Liebelt, A G; Congdon, C C; Stewart, H L

This is a report of mammary gland tumors from 62 guinea pigs. The tumors arose in the terminal ductal-lobular units as either lobular acinar carcinoma or cystadenocarcinoma or as papillary carcinomas within large ducts near the mammilla. About half the number of the males had terminal ductal-lobular carcinomas and all but 2 of the papillary duct carcinomas also arose in males. Large tumors frequently exhibited squamous, chondromatous, osseous, fatty and myoepitheliomatous types of tissues. In 2 irradiated males and 1 female the tumors metastasized. Whole-body irradiation did not produce significant changes in the number or sex distribution or in the morphology of mammary gland tumors in inbred or outbred guinea pigs. All females had cystic ovaries without increase in granulosa cells, 24 (66.6%) had uterine tumors and 13 (34.2%) had adrenal gland tumors; all males had atrophic testes, 5 (16.5%) had testicular and 6 (22.2%) had adrenal gland tumors.

• Research Organization: National Cancer Institute, Bethesda, MD
• OSTI ID: 6840840
• Journal Information: Toxicol. Pathol.; (United States), Journal Name: Toxicol. Pathol.; (United States) Vol. 3; ISSN TOPAD
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADRENAL GLANDS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CARCINOMAS
DISEASES
ENDOCRINE GLANDS
EXTERNAL IRRADIATION
FEMALE GENITALS
GLANDS
GONADS
GUINEA PIGS
IRRADIATION
MALE GENITALS
MAMMALS
MAMMARY GLANDS
NEOPLASMS
ORGANS
OVARIES
RADIATION EFFECTS
RODENTS
TESTES
UTERUS
VERTEBRATES
WHOLE-BODY IRRADIATION