Morphological and histological characteristics of mammary dysplasias occurring in cell dissociation-derived murine mammary outgrowths

Journal Article · Mon Oct 01 04:00:00 EDT 1984 · Cancer Res.; (United States)

OSTI ID:6308136

Ethier, S P; Adams, L M; Ullrich, R L

The morphological and histological characteristics of ductal dysplasias that were observed in mammary outgrowths derived from monodispersed mammary cells of carcinogen-treated mice are described. Mammary outgrowths were derived by injecting either 10(4) or 10(5) enzymatically dissociated mammary cells, obtained from control or carcinogen-treated BALB/c mice, into gland-free mammary fat pads of syngeneic hosts. The mammary dysplasias observed varied considerably in morphological and histological characteristics. The majority of the lesions were ductal in origin and were associated with epithelial hyperplasia which ranged from mild hyperplasia, in which only a few extra layers of epithelium were present, to severe hyperplasia, in which the ducts and end buds were occluded and distended with epithelial cells. In addition, papillary and lobular lesions were observed which were also associated with varying degrees of hyperplasia. The range of mammary dysplasias observed in these outgrowths closely resembles that of lesions associated with the pathogenesis of mammary carcinoma in mice, rats, and humans.

• Research Organization: Michigan Cancer Foundation, Detroit
• OSTI ID: 6308136
• Journal Information: Cancer Res.; (United States), Journal Name: Cancer Res.; (United States) Vol. 44:10; ISSN CNREA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
AROMATICS
BENZANTHRACENE
BODY
CARCINOGENESIS
CARCINOMAS
CELL PROLIFERATION
CONDENSED AROMATICS
DIMETHYLBENZANTHRACENE
DISEASES
GLANDS
HYDROCARBONS
MAMMALS
MAMMARY GLANDS
MICE
NEOPLASMS
ONCOGENIC TRANSFORMATIONS
ORGANIC COMPOUNDS
ORGANS
PATHOGENESIS
RODENTS
SOMATIC CELLS
TOXICITY
VERTEBRATES