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Title: Coronary heart disease and the zinc-to-copper ratio in human aorta and drinking water

Abstract

Trace levels of zinc and copper have been determined in the aorta from individuals with known histories of coronary heart disease (experimental group) and from individuals without a history of heart disease (control group) or any condition with an alleged or known association with trace zinc and copper. Subjects for the experimental and control groups were matched in terms of age, sex, and race. The zinc-to-copper ratio in the aorta for the experimental group was found to be significantly higher than the zinc-to-copper ratio in the control group at the 90% level of confidence. The results suggest that an imbalance in the zinc-to-copper ratio is a risk factor in coronary artery disease. Data for trace elements in major water sources for different geographical areas of the US from 1962-1967 were compiled and correlations with mortality rates for heart diseases from 1969-1971 were made. The results revealed that there was an extremely high correlation between the zinc-to-copper ratio in water and mortality rates of non-white females with coronary heart disease.

Authors:
; ; ; ;
Publication Date:
Research Org.:
Benedict College, Columbia, SC
OSTI Identifier:
6839898
Resource Type:
Journal Article
Resource Relation:
Journal Name: J. Tenn. Acad. Sci.; (United States); Journal Volume: 61:4
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; COPPER; BIOLOGICAL EFFECTS; CONCENTRATION RATIO; QUANTITY RATIO; TRACE AMOUNTS; MAN; INJURIES; ZINC; AORTA; CARDIOVASCULAR DISEASES; DRINKING WATER; ANIMALS; ARTERIES; BLOOD VESSELS; BODY; CARDIOVASCULAR SYSTEM; DISEASES; ELEMENTS; HYDROGEN COMPOUNDS; MAMMALS; METALS; ORGANS; OXYGEN COMPOUNDS; PRIMATES; TRANSITION ELEMENTS; VERTEBRATES; WATER 560300* -- Chemicals Metabolism & Toxicology

Citation Formats

Kinard, J.T., Moses, H.A., Stackhouse, C., Fludd, R., and Thompson, R.. Coronary heart disease and the zinc-to-copper ratio in human aorta and drinking water. United States: N. p., 1986. Web.
Kinard, J.T., Moses, H.A., Stackhouse, C., Fludd, R., & Thompson, R.. Coronary heart disease and the zinc-to-copper ratio in human aorta and drinking water. United States.
Kinard, J.T., Moses, H.A., Stackhouse, C., Fludd, R., and Thompson, R.. 1986. "Coronary heart disease and the zinc-to-copper ratio in human aorta and drinking water". United States. doi:.
@article{osti_6839898,
title = {Coronary heart disease and the zinc-to-copper ratio in human aorta and drinking water},
author = {Kinard, J.T. and Moses, H.A. and Stackhouse, C. and Fludd, R. and Thompson, R.},
abstractNote = {Trace levels of zinc and copper have been determined in the aorta from individuals with known histories of coronary heart disease (experimental group) and from individuals without a history of heart disease (control group) or any condition with an alleged or known association with trace zinc and copper. Subjects for the experimental and control groups were matched in terms of age, sex, and race. The zinc-to-copper ratio in the aorta for the experimental group was found to be significantly higher than the zinc-to-copper ratio in the control group at the 90% level of confidence. The results suggest that an imbalance in the zinc-to-copper ratio is a risk factor in coronary artery disease. Data for trace elements in major water sources for different geographical areas of the US from 1962-1967 were compiled and correlations with mortality rates for heart diseases from 1969-1971 were made. The results revealed that there was an extremely high correlation between the zinc-to-copper ratio in water and mortality rates of non-white females with coronary heart disease.},
doi = {},
journal = {J. Tenn. Acad. Sci.; (United States)},
number = ,
volume = 61:4,
place = {United States},
year = 1986,
month = 1
}
  • The mortality rate for coronary heart disease (CHD) and the ratio of zinc to copper in milk of 47 cities of the United States were correlated (r = 0.354, p < 0.02). The correlation was related to the production of hypercholesterolemia in rats by diets with a high ratio of Zn to Cu, the differences in ratios of human and cow milk and the human morbidity associated with the ingestion of diets with a high ratio. One eighth of the geographic variation in mortality due to CHD can be explained by this correlation. Breast feeding may be beneficial in regardmore » to risk of CHD. 29 references, 1 figure, 1 table.« less
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  • Uptake of thallium (Tl)-201 in the lungs has been proposed as a measure of left ventricular dysfunction. In this study we were interested in pursuing two goals: (1) to assess possible relationships between the post-exercise Tl-201 lung-heart (LH)-ratio determined from the anterior view during SPECT-acquisition, myocardial ischemia and the extent of coronary artery disease; and (2) to explore the effects of coronary revascularisation procedures on the LH-ratio. The study group consisted of 145 patients with early and late postexercise Tl-201 tomograms, including 32 PTCA-patients with pre- and post-PTCA studies and 20 patients who underwent coronary artery bypass surgery (CABG) withmore » corresponding pre- and post-CABG studies. Ischemia was defined as evoked angina during the exercise test in combination with greater than or equal to 1 mm horizontal or downsloping ST-depression on the ECG. The severity of coronary obstructions was assessed from coronary angiograms with a PC-based digital caliper technique; a stenosis was defined to be significant when its severity exceeded 50% diameter stenosis. The LH-ratio was defined by the ratio of the mean pulmonary counts and the mean myocardial counts assessed from corresponding regions of interest (ROI's) positioned over the left lung and the heart, respectively in the anterior view of a tomographic data acquisition procedure. Our results made clear that the LH-ratio was not significantly different between patients with and without ischemia during exercise, and between patients with single vs. multiple vessel disease.« less
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