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Coronary heart disease mortality after irradiation for Hodgkin's disease

Journal Article · · Cancer (Philadelphia); (United States)
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The authors conducted a study designed to evaluate the hypothesis that irradiation to the heart in the treatment for Hodgkin's disease (HD) is associated with increased coronary heart disease (CHD) mortality. This report describes 957 patients diagnosed with HD in 1942-75 and analyzes follow-up findings through December 1977. Twenty-five coronary heart disease deaths have been observed, and 4258.2 person-years of experience at risk have been accrued. The relative death rate (RDR), defined as the CHD mortality for heart-irradiated subjects divided by the mortality for nonirradiated subjects, was estimated. After adjustment for the effect of interval of observation, age, stage, and class, the RDR estimate is 1.5 but does not differ significantly from unit (95% confidence limits: 0.59, 3.7).
Research Organization:
Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts
OSTI ID:
7054613
Journal Information:
Cancer (Philadelphia); (United States), Journal Name: Cancer (Philadelphia); (United States) Vol. 49:12; ISSN CANCA
Country of Publication:
United States
Language:
English

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Related Subjects

550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560151* -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
COMPARATIVE EVALUATIONS
DIAGNOSIS
DISEASES
EPIDEMIOLOGY
EXTERNAL IRRADIATION
HEART
HODGKINS DISEASE
IRRADIATION
LYMPHOMAS
MEDICAL SURVEILLANCE
MEDICINE
MORTALITY
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
PATIENTS
RADIATION EFFECTS
RADIOINDUCTION
RADIOLOGY
RADIOTHERAPY
SIDE EFFECTS
SURVEILLANCE
THERAPY