Coronary heart disease after mediastinal irradiation for Hodgkin's disease

Journal Article · Thu Jan 01 04:00:00 EST 1976 · Am. J. Med.; (United States)

DOI:https://doi.org/10.1016/0002-9343(76)90531-3· OSTI ID:7352971

McReynolds, R A; Gold, G L; Roberts, W C

Attention is called to the development of coronary heart disease in two patients several years after they received mediastinal irradiation for Hodgkin's disease. One patient, a 33 year old man, died suddenly eight years after irradiation; necropsy disclosed marked narrowing of all three major coronary arteries. In addition to severe intima fibrous thickening, there also was considerable adventitial scarring of the coronary arteries. This type of coronary sclerosis is different from that seen in the usual patient with coronary heart disease. The second patient, a 42 year old man, had an acute myocardial infarction on two occasions, the first six years after mediastinal irradiation. Observations in previously described patients with coronary heart disease almost surely induced by therapeutic irradiation for Hodgkin's disease are reviewed.

• Research Organization: National Institutes of Health, Bethesda, MD
• OSTI ID: 7352971
• Journal Information: Am. J. Med.; (United States), Journal Name: Am. J. Med.; (United States) Vol. 60; ISSN AJMEA
• Country of Publication: United States
• Language: English

Related Subjects

560151* -- Radiation Effects on Animals-- Man
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
DELAYED RADIATION EFFECTS
DISEASES
HEART
HODGKINS DISEASE
LYMPHOMAS
MEDICINE
MUSCLES
MYOCARDIAL INFARCTION
MYOCARDIUM
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
PATIENTS
RADIATION EFFECTS
RADIOINDUCTION
RADIOLOGY
RADIOTHERAPY
SIDE EFFECTS
THERAPY