Virus-induced cellular immunity to simian virus 40 tumor-specific surface antigen(s) in adult LVG:LAK hamsters

Journal Article · Tue Apr 01 04:00:00 EST 1980 · J. Natl. Cancer Inst.; (United States)

OSTI ID:6839415

Weppner, W A ^[1]; Coggin, Jr, J H

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1. Univ. of South Alabama, Mobile

Cell-mediated immunity directed against simian virus 40 (SV40) tumor-specific surface antigen(s) (TSSA) was detected in SV40-immunized noninbred LVG:LAK hamsters with the use of a lymphocyte transformation assay. Sensitized spleen cells underwent a proliferative response in the presence of cells of an SV40-induced hamster sarcoma cell line (WF5-1) or the plasma membranes from these cells. These results established that immunization of adult hamsters with SV40 resulted in a specific autochthonous cell-mediated immune response against SV40 TSSA. The in vitro demonstration of this virus-induced immunity provided a unique method for the investigation of the SV40 TSSA involved in the establishment or rejection of tumors. The described lymphocyte transformation assay was also used to follow the solubilization and purification of the SV40 TSSA.

• OSTI ID: 6839415
• Journal Information: J. Natl. Cancer Inst.; (United States), Journal Name: J. Natl. Cancer Inst.; (United States) Vol. 64:4; ISSN JNCIA
• Country of Publication: United States
• Language: English

Related Subjects

550700* -- Microbiology
59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
ANIMALS
ANTIGENS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CARCINOGENESIS
CELL CULTURES
CELL PROLIFERATION
CONNECTIVE TISSUE CELLS
DISEASES
HAMSTERS
IMMUNITY
LEUKOCYTES
LYMPHOCYTES
MAMMALS
MATERIALS
MICROORGANISMS
NEOPLASMS
PARASITES
PATHOGENESIS
RODENTS
SARCOMAS
SIMIAN VIRUS
SOMATIC CELLS
SPLEEN CELLS
VERTEBRATES
VIRUSES