Characterization of immune responses to spontaneous hamster lymphomas
Journal Article
·
· J. Natl. Cancer Inst.; (United States)
OSTI ID:6184374
Tumor resistance could be induced against the transplantation of cell lines derived from spontaneous lymphomas that occurred in the third of three lymphoma epizootics in a hamster colony. Immunization of normal hamsters with irradiated lymphoma cells promoted resistance to homologous lymphoma challenge and prevented the development of spontaneous lymphomas when immunized hamsters were exposed to the contaminated colony. This immunity could be transferred in an adoptive transfer assay. Resistance to direct challenge was not extended to simian virus 40 (SV40)-induced sarcomas carrying SV40 tumor-specific transplantation antigen nor to herpesvirus-induced carcinoma cells, indicating specificity. The nature of the antigen(s) involved was discussed.
- Research Organization:
- Univ. of Tennessee, Knoxville
- OSTI ID:
- 6184374
- Journal Information:
- J. Natl. Cancer Inst.; (United States), Journal Name: J. Natl. Cancer Inst.; (United States) Vol. 58:5; ISSN JNCIA
- Country of Publication:
- United States
- Language:
- English
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550300 -- Cytology
560134 -- Radiation Effects on Microorganisms-- Vaccine Preparation & Other Applications-- (-1987)
560152* -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ANTIGENS
BIOASSAY
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CARCINOMAS
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ELECTROMAGNETIC RADIATION
HAMSTERS
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IMMUNITY
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MICROORGANISMS
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RADIATION EFFECTS
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VERTEBRATES
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560134 -- Radiation Effects on Microorganisms-- Vaccine Preparation & Other Applications-- (-1987)
560152* -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ANTIGENS
BIOASSAY
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CARCINOMAS
DISEASES
ELECTROMAGNETIC RADIATION
HAMSTERS
IMMUNE REACTIONS
IMMUNITY
IONIZING RADIATIONS
LYMPHOMAS
MAMMALS
MICROORGANISMS
NEOPLASMS
PARASITES
RADIATION EFFECTS
RADIATIONS
RODENTS
SARCOMAS
VACCINES
VERTEBRATES
VIRUSES
X RADIATION