Suppression of hamster lymphocyte reactivity to simian virus 40 tumor surface antigens by spleen cells from pregnant hamsters

Journal Article · Mon Sep 01 04:00:00 EDT 1980 · Cell. Immunol.; (United States)

DOI:https://doi.org/10.1016/0008-8749(80)90224-5· OSTI ID:6808366

Weppner, W A; Adkinson, L R; Coggin, Jr, J H

SV40-transformed tumor cells in hamsters have been found to have cell surface antigens cross-reactive with antigens temporally expressed on fetal tissues. Using a lymphocyte transformation assay, spleen cells from pregnant hamsters were found to be incapable of responding to preparations of either hamster fetal tissue or SV40-transformed cells. However, a suppressor component can be demonstrated in spleen cell populations of both primi-and multiparous hamsters during pregnancy that is capable of reducing the response of lymphocytes sensitized against SV40 tumor-associated antigens. The degree of suppression is proportional to the ratio of responder cells to spleen cells from pregnant animals. These results suggest there is a subpopulation of spleen cells involved in immunoregulation during pregnancy that has the ability to suppress the reactivity of lymphocytes sensitized against SV40-associated oncofetal antigens.

• Research Organization: Univ. of South Alabama, Mobile
• OSTI ID: 6808366
• Journal Information: Cell. Immunol.; (United States), Journal Name: Cell. Immunol.; (United States) Vol. 54:No. 2; ISSN CLIMB
• Country of Publication: United States
• Language: English

Related Subjects

550300 -- Cytology
551000* -- Physiological Systems
59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
ANIMALS
ANTIGENS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CONNECTIVE TISSUE CELLS
HAMSTERS
IMMUNOSUPPRESSION
LEUKOCYTES
LYMPHOCYTES
MAMMALS
MATERIALS
MICROORGANISMS
PARASITES
PREGNANCY
RODENTS
SIMIAN VIRUS
SOMATIC CELLS
SPLEEN CELLS
TUMOR CELLS
VERTEBRATES
VIRUSES