Sensitivity to. gamma. rays of avian sarcoma and murine leukemia viruses. [/sup 60/Co, uv]

Journal Article · Mon Sep 01 04:00:00 EDT 1980 · Virology; (United States)

DOI:https://doi.org/10.1016/0042-6822(80)90051-3· OSTI ID:6839330

Toyoshima, K ^[1]; Niwa, O; Yutsudo, M; Sugiyama, H; Tahara, S; Sugahara, T

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1. Osaka Univ., Japan

The direct inactivation of avian and murine oncoviruses by ..gamma.. rays was examined using /sup 60/Co as a ..gamma..-ray source. The inactivation of murine leukemia virus (M-MuLV) followed single-hit kinetics while the subgroup D Schmidt-Ruppin strain of avian sarcoma virus (SR-RSV D) showed multihit inactivation kinetics with an extrapolation number of 5. The two viruses showed similar uv-inactivation kinetics. The genomic RNA of the SR-RSV D strain was degraded by ..gamma.. irradiation faster than its infectivity, but viral clones isolated from the foci formed after ..gamma.. irradiation had a complete genome. These results suggest that SR-RSV D has a strong repair function, possibly connected with reverse transcriptase activity.

• OSTI ID: 6839330
• Journal Information: Virology; (United States), Journal Name: Virology; (United States) Vol. 105:2; ISSN VIRLA
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
COBALT 60
COBALT ISOTOPES
COMPARATIVE EVALUATIONS
DOSE-RESPONSE RELATIONSHIPS
EARLY RADIATION EFFECTS
ELECTROMAGNETIC RADIATION
GAMMA RADIATION
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LEUKEMIA VIRUSES
MICROORGANISMS
MINUTES LIVING RADIOISOTOPES
NUCLEI
NUCLEIC ACIDS
ODD-ODD NUCLEI
ONCOGENIC VIRUSES
ORGANIC COMPOUNDS
PARASITES
PLAQUE FORMATION
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOISOTOPES
RECOVERY
REPAIR
RNA
STRAND BREAKS
SURVIVAL CURVES
ULTRAVIOLET RADIATION
VIRUSES
YEARS LIVING RADIOISOTOPES