Ozone uptake in awake Sprague-Dawley rats

Technical Report · Thu Jan 01 04:00:00 EST 1987

OSTI ID:6834922

Wiester, M J; Williams, T B; King, M E; Menache, M G; Miller, F J

Knowledge of ozone (O/sub 3/) uptake in rats is integral to efforts to quantitatively extrapolate animal data to man. The authors measured percent uptake of 30 adult Sprague-Dawley rats exposed, nose only, for 1 hr to 0.3, 0.6 or 1.0 ppm O/sub 3/. Resting breathing measurements were obtained by plethysmography while changes in ozone, oxygen, and carbon dioxide, due to animal breathing, were computed. Ozone uptake was calculated by a fractional deposition technique, i.e. O/sub 3/ in vs. O/sub 3/ out. Pulmonary O/sub 3/ uptake was found to be approximately 40% of that inspired. The value did not vary over time nor was it affected by O/sub 3/ concentration. Although ozone uptake did not appear to be influenced by ventilatory changes within normal breathing limits, it was positively correlated with respiratory gas exchange. The quantitative retention of O/sub 3/ by the respiratory epithelium increased proportionally with O/sub 3/ concentration and minute volume.

• Research Organization: Environmental Protection Agency, Research Triangle Park, NC (USA). Health Effects Research Lab.
• OSTI ID: 6834922
• Report Number(s): PB-88-223284/XAB; EPA-600/J-87/366
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
INHALATION
INTAKE
LABORATORY ANIMALS
MAMMALS
OZONE
RATS
RESPIRATORY SYSTEM
RODENTS
UPTAKE
VERTEBRATES