Ozone uptake in awake Sprague-Dawley rats

Journal Article · Wed Jul 01 04:00:00 EDT 1987 · Toxicol. Appl. Pharmacol.; (United States)

DOI:https://doi.org/10.1016/0041-008X(87)90162-1· OSTI ID:6272104

Wiester, M J; Williams, T B; King, M E; Menache, M G; Miller, F J

Knowledge of ozone (O/sub 3/) uptake in rats in integral to efforts to quantitatively extrapolate animal data to man. We have measured percentage O/sub 3/ uptake in 30 adult Sprague-Dawley rats exposed, nose only, for 1 hr to 0.3, 0.6, or 1.0 ppm O/sub 3/. Tidal volume and breathing rate measurements, obtained by plethysmography, were time-matched with changes in airstream concentrations of O/sub 3/, oxygen, and carbon dioxide, due to animal breathing, for computation of O/sub 3/ uptake and respiratory gas exchange values. Ozone uptake was calculated by a fractional deposition technique, i.e. O/sub 3/ in vs O/sub 3/ out. Total respiratory system O/sub 3/ uptake was found to be approximately 40% of that inspired and did not vary with O/sub 3/ concentration nor during the 1-hr exposure. The quantity of O/sub 3/ inhaled and retained by the rat increased proportionally with O/sub 3/ concentration.

• Research Organization: Environmental Protection Agency, Research Triangle Park, NC
• OSTI ID: 6272104
• Journal Information: Toxicol. Appl. Pharmacol.; (United States), Journal Name: Toxicol. Appl. Pharmacol.; (United States) Vol. 89:3; ISSN TXAPA
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
DOGS
DOSE-RESPONSE RELATIONSHIPS
GUINEA PIGS
MAMMALS
OZONE
PARTIAL PRESSURE
RABBITS
RATS
RETENTION
RODENTS
UPTAKE
VERTEBRATES