Experimental measurements of the uptake of ozone in rats and human subjects
Technical Report
·
OSTI ID:5516862
Experimental determination of ozone (O/sub 3/) uptake in the conducting airways and lungs is a fundamental starting point for interspecies comparisons of delivered dose. Fractional O/sub 3/ uptake was measured in the respiratory tract of awake Fischer 344 rats and in the lungs and nasopharynx of young healthy male humans. Awake animals were individually evaluated during nose only exposures to 0.3 ppm O/sub 3/ for O/sub 3/ removal, O/sub 2/ consumption, CO/sub 2/ production and tidal breathing while inside a body plethysmograph. Utilizing these values of O/sub 3/ uptake and measures of ventilation, the mass dose rate of O/sub 3/ per unit respiratory tract surface area was computed and found to be similar between rats and humans for the same ambient O/sub 3/ concentration.
- Research Organization:
- Environmental Protection Agency, Research Triangle Park, NC (USA). Health Effects Research Lab.
- OSTI ID:
- 5516862
- Report Number(s):
- PB-88-125422/XAB; EPA-600/D-87/319
- Country of Publication:
- United States
- Language:
- English
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