Model of the regional uptake of gaseous pollutants in the lung. II. The sensitivity of ozone uptake in laboratory animal lungs to anatomical and ventilatory parameters

Journal Article · Fri May 01 04:00:00 EDT 1987 · Toxicol. Appl. Pharmacol.; (United States)

DOI:https://doi.org/10.1016/0041-008X(87)90216-X· OSTI ID:6497358

Overton, J H; Graham, R C; Miller, F J

An O/sub 3/ dosimetry model is used to simulate the local absorption of O/sub 3/ in the lower respiratory tract of rats and guinea pigs. The model takes into account lower respiratory tract anatomy, transport in the lumen and air spaces, and transport and chemical reactions in the mucous and surfactant layers and in the underlying tissue and capillaries. For each species two anatomical models were used to investigate their influence in predicting absorption. Results with all four anatomical models and various ventilatory parameters showed a qualitative similarity in the shape of the dose versus airway number curves but significant differences in predicted percentage total and percentage pulmonary uptake. The percentage uptake was also sensitive to breathing frequency and tidal volume. Rat lobe models were used to study absorption in lobes and show that O/sub 3/ tissue dose in centriacinar regions decreases with increasing distance from the trachea. The effect on results of values used for functional residual capacity and of values used for the chemical rate constants for O/sub 3/ reactions in mucous were explored. Results differed quantitatively but not qualitatively.

• Research Organization: Environmental Protection Agency, Research Triangle Park, NC
• OSTI ID: 6497358
• Journal Information: Toxicol. Appl. Pharmacol.; (United States), Journal Name: Toxicol. Appl. Pharmacol.; (United States) Vol. 3; ISSN TXAPA
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AIR POLLUTION
ANIMALS
BIOLOGICAL MODELS
BODY
GUINEA PIGS
LUNGS
MAMMALS
MATHEMATICAL MODELS
MEMBRANE TRANSPORT
ORGANS
OZONE
POLLUTION
RATS
RESPIRATION
RESPIRATORY SYSTEM
RODENTS
SENSITIVITY
TOXICITY
UPTAKE
VERTEBRATES