Mathematical modeling of ozone absorption in the lower respiratory tract
Technical Report
·
OSTI ID:6922419
A mathematical O/sub 3/ dosimetry model was developed for simulating the local absorption of O/sub 3/ in the lower respiratory tract (LRT) of animals and man. The model takes into account LRT anatomy, transport in the lumen and air spaces, and transport and chemical reactions in the liquid layers and in the underlying tissue and capillaries. Differential equations are used to describe the processes of transport and chemical reactions; solutions are obtained numerically. Simulations are illustrated with results of two investigations: the effect of anatomical models on predicted LRT uptake of O/sub 3/ in rat and guinea pig, and the effect of exercise on the uptake and distribution of ozone in the LRT of man.
- Research Organization:
- Environmental Protection Agency, Research Triangle Park, NC (USA). Health Effects Research Lab.
- OSTI ID:
- 6922419
- Report Number(s):
- PB-88-225073/XAB; EPA-600/D-88/141
- Country of Publication:
- United States
- Language:
- English
Similar Records
Modeling ozone absorption in the lower respiratory tract
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Technical Report
·
Tue Mar 31 23:00:00 EST 1987
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OSTI ID:6407319
Model of the regional uptake of gaseous pollutants in the lung. 2. The sensitivity of ozone uptake in laboratory animal lungs to anatomical and ventilatory parameters
Technical Report
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Wed Dec 31 23:00:00 EST 1986
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OSTI ID:5270175
Model of the regional uptake of gaseous pollutants in the lung. II. The sensitivity of ozone uptake in laboratory animal lungs to anatomical and ventilatory parameters
Journal Article
·
Fri May 01 00:00:00 EDT 1987
· Toxicol. Appl. Pharmacol.; (United States)
·
OSTI ID:6497358
Related Subjects
500200 -- Environment
Atmospheric-- Chemicals Monitoring & Transport-- (-1989)
54 ENVIRONMENTAL SCIENCES
560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSORPTION
AIR POLLUTION
ANIMAL CELLS
CHEMICAL REACTIONS
INHALATION
INTAKE
MATHEMATICAL MODELS
OZONE
POLLUTION
RESPIRATORY SYSTEM
RESPIRATORY TRACT CELLS
SORPTIVE PROPERTIES
SURFACE PROPERTIES
Atmospheric-- Chemicals Monitoring & Transport-- (-1989)
54 ENVIRONMENTAL SCIENCES
560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSORPTION
AIR POLLUTION
ANIMAL CELLS
CHEMICAL REACTIONS
INHALATION
INTAKE
MATHEMATICAL MODELS
OZONE
POLLUTION
RESPIRATORY SYSTEM
RESPIRATORY TRACT CELLS
SORPTIVE PROPERTIES
SURFACE PROPERTIES