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Diagnosis of delayed cerebral radiation necrosis following proton beam therapy

Journal Article · · Archives of Neurology; (USA)
; ; ; ; ;  [1]
  1. Wadsworth Veterans Administration Medical Center, Los Angeles, CA (USA)
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A 27-year-old man developed delayed cerebral radiation necrosis following proton beam therapy to an arteriovenous malformation. Neuroimaging with technetium 99m diethylenetriamine penta-acetic acid and positron emission tomographic scanning with fludeoxyglucose F 18 aided in his evaluation. Significant improvement of his neurologic deficits resulted from corticosteroid therapy. Clinical resolution was corroborated by serial computed tomographic scans demonstrating regression of the abnormality (a mass lesion). Various facets of radiation injury are discussed, including pathogenesis, risk factors, diagnosis, and therapy.
OSTI ID:
6833539
Journal Information:
Archives of Neurology; (USA), Journal Name: Archives of Neurology; (USA) Vol. 47:4; ISSN 0003-9942; ISSN ARNEA
Country of Publication:
United States
Language:
English

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Related Subjects

550601 -- Medicine-- Unsealed Radionuclides in Diagnostics
560151* -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADRENAL HORMONES
AMINO ACIDS
ANIMALS
BEAMS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BRAIN
CARBOXYLIC ACIDS
CENTRAL NERVOUS SYSTEM
CHELATING AGENTS
CORTICOSTEROIDS
DRUGS
DTPA
FLUORINE 18
FLUORINE ISOTOPES
HOURS LIVING RADIOISOTOPES
HYDROXY COMPOUNDS
INJURIES
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KETONES
LIGHT NUCLEI
MAMMALS
MAN
MEDICINE
NECROSIS
NERVOUS SYSTEM
NUCLEAR MEDICINE
NUCLEI
NUCLEON BEAMS
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PARTICLE BEAMS
PATHOLOGICAL CHANGES
PREGNANES
PRIMATES
PROTON BEAMS
RADIATION EFFECTS
RADIATION INJURIES
RADIOISOTOPES
RADIOLOGY
RADIOPROTECTIVE SUBSTANCES
RADIOTHERAPY
SIDE EFFECTS
STEROIDS
TECHNETIUM 99
TECHNETIUM ISOTOPES
THERAPY
VERTEBRATES
YEARS LIVING RADIOISOTOPES