Challenges With the Diagnosis and Treatment of Cerebral Radiation Necrosis

Journal Article · Fri Nov 01 04:00:00 EDT 2013 · International Journal of Radiation Oncology, Biology and Physics

DOI:https://doi.org/10.1016/J.IJROBP.2013.05.015· OSTI ID:22267904

Ahluwalia, Manmeet S. ^[1]; Barnett, Gene H. ^[2]; Stevens, Glen H.J. ^[3]; Murphy, Erin S. ^[4]; Stockham, Abigail L. ^[4]; Shiue, Kevin ^[5]; Suh, John H. ^[4]

---

1. Department of Medical Oncology, Cleveland Clinic, Cleveland, Ohio (United States)
2. Department of Neurosurgery, Cleveland Clinic, Cleveland, Ohio (United States)
3. Department of Neurology, Cleveland Clinic, Cleveland, Ohio (United States)
4. Department of Radiation Oncology, Cleveland Clinic, Cleveland, Ohio (United States)
5. Case Western Reserve University School of Medicine, Cleveland, Ohio (United States)

The incidence of radiation necrosis has increased secondary to greater use of combined modality therapy for brain tumors and stereotactic radiosurgery. Given that its characteristics on standard imaging are no different that tumor recurrence, it is difficult to diagnose without use of more sophisticated imaging and nuclear medicine scans, although the accuracy of such scans is controversial. Historically, treatment had been limited to steroids, hyperbaric oxygen, anticoagulants, and surgical resection. A recent prospective randomized study has confirmed the efficacy of bevacizumab in treating radiation necrosis. Novel therapies include using focused interstitial laser thermal therapy. This article will review the diagnosis and treatment of radiation necrosis.

• OSTI ID: 22267904
• Journal Information: International Journal of Radiation Oncology, Biology and Physics, Journal Name: International Journal of Radiation Oncology, Biology and Physics Journal Issue: 3 Vol. 87; ISSN IOBPD3; ISSN 0360-3016
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
ACCURACY
ANTICOAGULANTS
BRAIN
DIAGNOSIS
NECROSIS
NEOPLASMS
OXYGEN
RADIOTHERAPY
SURGERY