Selenium-75-labeled sucralfate: comparison with other radiolabels and initial clinical studies

Journal Article · Fri Jan 01 00:00:00 EST 1988 · Am. J. Physiol. Imag.; (United States)

OSTI ID:6827561

Knight, L C; Maurer, A H; Kollmann, M; Ammar, I A; Fisher, R S; Malmud, L S

Sucralfate was synthesized to include a /sup 75/Se label, then compared with /sup 111/In-sucralfate and /sup 99m/Tc-Human serum albumin (HSA)-sucralfate in vitro and in an animal ulcer model. The /sup 75/Se label was the only one of the three that was stable in both human gastric juice and simulated intestinal fluid in vitro. In rats with gastric ulcers, ulcer:nonulcer ratios of bound radioactivity averaged 15.4, 6.3, and 5.6 for /sup 75/Se, /sup 111/In, and /sup 99m/Tc-HSA labels, respectively. Biodistribution studies of /sup 75/Se-sucralfate indicated that little is absorbed from the gastrointestinal tract, and the distribution is similar to that of /sup 14/C-sucralfate. Selective binding of /sup 75/Se sucralfate was successfully imaged in patients with esophagitis (esophageal mean T1/2 binding = 65 +/- 32 min), gastritis (gastric mean T 1/2 binding = 118 +/- 34 min), and gastric ulcers (ulcer mean T 1/2 binding = 135 +/- 59 min). Duodenal ulcers were not successfully imaged. Normal subjects showed no abnormal localization of sucralfate, and esophageal and gastric clearances were rapid.

• Research Organization: Temple Univ. Hospital, Philadelphia, PA (USA)
• OSTI ID: 6827561
• Journal Information: Am. J. Physiol. Imag.; (United States), Vol. 3:1
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
ALUMINIUM COMPLEXES
TISSUE DISTRIBUTION
DIGESTIVE SYSTEM DISEASES
DIAGNOSIS
RADIOPHARMACEUTICALS
COMPARATIVE EVALUATIONS
BIOLOGICAL MODELS
INDIUM 111
INTESTINAL ABSORPTION
ISOMERIC NUCLEI
RATS
SELENIUM 75
TECHNETIUM 99
TRACER TECHNIQUES
ULCERS
ABSORPTION
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
COMPLEXES
DAYS LIVING RADIOISOTOPES
DISEASES
DISTRIBUTION
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
HOURS LIVING RADIOISOTOPES
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
MAMMALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
PATHOLOGICAL CHANGES
RADIOISOTOPES
RODENTS
SELENIUM ISOTOPES
TECHNETIUM ISOTOPES
UPTAKE
VERTEBRATES
YEARS LIVING RADIOISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics