Chemical aspects of labeling sucralfate with /sup 99m/TcO/sub 4/
Journal Article
·
· J. Nucl. Med.; (United States)
OSTI ID:5820918
Two formulations of (/sup 99m/Tc)sucralfate have been used to image gastric and duodenal ulcers and inflammatory bowel disease. One formulation is a complexation of (/sup 99m/Tc)HSA with sucralfate. The second is prepared by directly labeling sucralfate with (/sup 99m/Tc)pertechnetate in the presence of stannous ion. An in vitro study of the factors affecting the production and stability of these labeled sucralfate preparations was conducted. Both formulations were stable at the acidic pH likely encountered in the stomach. However, at pH greater than 6 the albumin-sucralfate complex began to dissociate while directly labeled sucralfate was stable to a pH of 9. Conversely it was shown that directly labeled sucralfate was more susceptible to loss of /sup 99m/Tc to other chelating species. Sucralfate complexed with (/sup 99m/Tc)HSA was radiochemically stable up to a specific activity of 26 GBq (700 mCi) per gram while directly labeled sucralfate showed decreased 24-hr stability at specific activities greater than 837 mCi (31 GBq) per gram.
- Research Organization:
- Health Sciences Centre, Winnipeg, Manitoba (Canada)
- OSTI ID:
- 5820918
- Journal Information:
- J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 30:4; ISSN JNMEA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ALBUMINS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
DIAGNOSIS
DIGESTIVE SYSTEM
DIGESTIVE SYSTEM DISEASES
DISEASES
DRUGS
GASTROINTESTINAL TRACT
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANOMETALLIC COMPOUNDS
ORGANS
OXYGEN COMPOUNDS
PATHOLOGICAL CHANGES
PERTECHNETATES
PROTEINS
RADIOISOTOPES
RADIOPHARMACEUTICALS
REFRACTORY METAL COMPOUNDS
STABILITY
STOMACH
TECHNETIUM 99
TECHNETIUM COMPOUNDS
TECHNETIUM ISOTOPES
TRANSITION ELEMENT COMPOUNDS
ULCERS
YEARS LIVING RADIOISOTOPES
62 RADIOLOGY AND NUCLEAR MEDICINE
ALBUMINS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
DIAGNOSIS
DIGESTIVE SYSTEM
DIGESTIVE SYSTEM DISEASES
DISEASES
DRUGS
GASTROINTESTINAL TRACT
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANOMETALLIC COMPOUNDS
ORGANS
OXYGEN COMPOUNDS
PATHOLOGICAL CHANGES
PERTECHNETATES
PROTEINS
RADIOISOTOPES
RADIOPHARMACEUTICALS
REFRACTORY METAL COMPOUNDS
STABILITY
STOMACH
TECHNETIUM 99
TECHNETIUM COMPOUNDS
TECHNETIUM ISOTOPES
TRANSITION ELEMENT COMPOUNDS
ULCERS
YEARS LIVING RADIOISOTOPES