Validation of binding of SE-75 labeled sucralfate to sites of gastrointestinal ulceration

Conference · Wed May 01 04:00:00 EDT 1985 · J. Nucl. Med.; (United States)

OSTI ID:5872204

Maurer, A H; Knight, L C; Kollman, M; Krevsky, B; Pleet, D; D'Ercole, F; Siegel, J A; Fisher, R S; Malmud, L S

This study was performed to determine if and for how long sucralfate (SU) binds selectively to sites of gastro-intestinal (GI) ulceration. Se-Su was prepared by sulfating sucrose with tracer Se-75 and precipitating it as the basic Al salt. All patients (pts) had endoscopy to confirm the presence of either: esophagitis (n=5), gastritis (GA) (n=5), gastric ulcers (GU) (n=5), duodenal ulcers (DU) (n=5), or no ulceration (NU) (n=5). Following an overnight fast the pts swallowed 1 gm with 100 ..mu..Ci of Se-SU and were imaged continuously over 24 hours or until no activity remained in the upper GI tract. Pts with GU visually demonstrated focal SU binding at the ulcers for an average of 3.9 +- 1.1 hrs. with a mean GET of 68 +- 25 min. Mean GET for pts with DU was prolonged, 171 +- 63 min, however focal binding at duodenal ulcers was not seen. All pts with GA had diffuse retention of SU in the stomach with a mean GET of 118 +- 34 min. Focal binding of SU at all sites of esophagitis was seen with a T-1/2 of 65 +- 32 min at the ulcerations. In conclusion these data support the theory that the mechanism of ulcer healing with SU is related to its ability to adhere to the ulcer site forming a protective barrier. In addition Se-SU is a potential ulcer imaging agent which can be used to noninvasively assess healing.

• Research Organization: Temple Univ. Health Sciences Center, Philadelphia, PA
• OSTI ID: 5872204
• Report Number(s): CONF-850611-
• Conference Information: Journal Name: J. Nucl. Med.; (United States) Journal Volume: 26:5
• Country of Publication: United States
• Language: English

Related Subjects

550501 -- Metabolism-- Tracer Techniques
550601 -- Medicine-- Unsealed Radionuclides in Diagnostics
550604* -- Medicine-- Unsealed Radionuclides in Therapy-- (1980-)
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ALUMINIUM COMPOUNDS
ALUMINIUM SULFATES
BETA DECAY RADIOISOTOPES
BIOLOGICAL RECOVERY
BODY
CARBOHYDRATES
CHEMICAL PREPARATION
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DIGESTIVE SYSTEM
DISACCHARIDES
DISTRIBUTION
DRUGS
DYNAMIC FUNCTION STUDIES
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
FUNCTIONS
GASTROINTESTINAL TRACT
HEALING
INTERMEDIATE MASS NUCLEI
ISOTOPES
LABELLED COMPOUNDS
LABELLING
MEDICINE
NUCLEAR MEDICINE
NUCLEI
OLIGOSACCHARIDES
ORAL ADMINISTRATION
ORGANIC COMPOUNDS
ORGANS
OXYGEN COMPOUNDS
PATHOLOGICAL CHANGES
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOLOGY
RADIONUCLIDE KINETICS
RADIOPHARMACEUTICALS
RADIOTHERAPY
RECOVERY
RETENTION FUNCTIONS
SACCHARIDES
SACCHAROSE
SCINTISCANNING
SELENIUM 75
SELENIUM ISOTOPES
STOMACH
SULFATES
SULFUR COMPOUNDS
SYNTHESIS
THERAPEUTIC USES
THERAPY
TISSUE DISTRIBUTION
ULCERS
UPTAKE
USES