Interim report on the genetic and animal toxicity testing of SRC-I products, intermediates, and waste materials

Technical Report · Thu Sep 01 04:00:00 EDT 1983

OSTI ID:6821197

Drozdowicz, B Z; Kelly, C M

This report presents the interim results of the genetic and animal toxicity testing program; of SRC-I products, process intermediates, and waste materials. It also discusses the structure of the program, including the philosophy underlying its design, as well as the sources, processing, and sample handling of the materials tested. Finally, it summarizes the results of the tests completed at the time when the Baseline Design package was prepared, and discusses the effects of these results on the health risk assessment and environmental impact analysis process. The appendices present the original reports that are complete. The genetic toxicity testing program indicated that the following substances are mutagenic: DMSO extracts of first- and second-stage solid products, as well as aqueous and saline suspensions of solids; all liquid products except hydrotreated naphthas; DMSO extractions of CSD ash concentrate; raw wastewaters; coker liquids; and residual fuel. Except for aqueous and saline suspensions of solid products, these results were generally anticipated. Genetic toxicity testing indicated that the following substances are not mutagenic: aqueous extracts of solid products and of gasifier fly ash, treated wastewaters, hydrotreated naphtha, and combustion fly ash. Acute toxicity tests indicated that the solid products are mildly irritating to eyes, but are not primary skin irritants. Acute inhalation toxicity tests of solids showed no significant effects. Middle distillates were rated slightly toxic to toxic orally, are mild primary irritants and probable skin sensitizers, and are severely irritating to eyes. Range finding tests for long-term skin painting and dermal teratology tests established the dosages to be used in these programs, and further confirmed the skin irritation properties of the middle distillate liquids.

• Research Organization: International Coal Refining Co., Allentown, PA (USA)
• DOE Contract Number: AC05-78OR03054
• OSTI ID: 6821197
• Report Number(s): DOE/OR/03054-50; ON: DE84013337
• Country of Publication: United States
• Language: English

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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOL WASTES
ANIMALS
AROMATICS
ASHES
COAL LIQUEFACTION
DATA
DISTILLATES
DMSO
EXPERIMENTAL DATA
EXTRACTION
FLY ASH
HAZARDS
HEALTH HAZARDS
HYDROGEN COMPOUNDS
HYDROXY COMPOUNDS
INDUSTRIAL MEDICINE
INFORMATION
LIQUEFACTION
LIQUID WASTES
MEDICINE
MUTAGEN SCREENING
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
OXYGEN COMPOUNDS
PHENOL
PHENOLS
RESIDUES
RISK ASSESSMENT
SCREENING
SEPARATION PROCESSES
SLAGS
SOLVENT EXTRACTION
SRC PROCESS
SULFOXIDES
THERMOCHEMICAL PROCESSES
TOXICITY
WASTE WATER
WASTES
WATER