Acute toxicity of selected crude and refined shale oil derived and petroleum-derived substances

Conference · Tue Jan 01 04:00:00 EST 1980

OSTI ID:5243202

Smith, L. H.; Haschek, W. M.; Witschi, H.

General information was obtained on the toxicity of selected samples of crude Paraho shale oil and some of its derivatives, some crude petroleums, and 3 refined petroleum products. Five tests were used to determine the acute toxicity of these substances: acute lethality in mice following oral or intraperitoneal administration of a single dose; acute dermal toxicity of a single dose in rats; delayed-type allergic contact hypersensitivity in guinea pigs; primary eye irritation and primary skin irritation of a single dose in rabbits. Histopathologic changes induced in mice following intraperitoneal injection of a single large dose of crude shale oil and two of its hydrotreated derivatives were examined. Studies also have been initiated to examine the tumor inducing potential of selected samples. The test system used was the mouse lung adenoma bioassay. The present report describes our findings and shows that all compounds tested have very low or no acute toxic effects in laboratory animals.

• Research Organization: Oak Ridge National Lab., TN (USA)
• DOE Contract Number: W-7405-ENG-26
• OSTI ID: 5243202
• Report Number(s): CONF-800680-1
• Country of Publication: United States
• Language: English

Related Subjects

02 PETROLEUM
020600 -- Petroleum-- Health & Safety
04 OIL SHALES AND TAR SANDS
040700 -- Oil Shales & Tar Sands-- Health & Safety
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACUTE EXPOSURE
ANIMALS
BODY
BODY AREAS
CARCINOGENESIS
DATA
DISEASES
DOSES
ENERGY SOURCES
EXPERIMENTAL DATA
EYES
FACE
FOSSIL FUELS
FUELS
GUINEA PIGS
HEAD
INFORMATION
LABORATORY ANIMALS
LETHAL DOSES
LUNGS
MAMMALS
MICE
MINERAL OILS
NUMERICAL DATA
OILS
ORGANIC COMPOUNDS
ORGANS
OTHER ORGANIC COMPOUNDS
PATHOGENESIS
PATHOLOGICAL CHANGES
PETROLEUM
RABBITS
RATS
RESPIRATORY SYSTEM
RODENTS
SENSE ORGANS
SHALE OIL
SHALE OIL FRACTIONS
SKIN
SYNTHETIC FUELS
SYNTHETIC PETROLEUM
TOXICITY
VERTEBRATES