Acute toxic effects of two crude shale oils and two standard petroleum crude oils applied to mouse skin

Technical Report · Wed Aug 01 04:00:00 EDT 1979

DOI:https://doi.org/10.2172/6135411· OSTI ID:6135411

Wilson, J S; Holland, L M

The acute dermal toxicity of two crude shale oils and two crude petroleums was studied, in an effort, to establish threshold tolerance levels for use in a subsequent epidermal carcinogenesis experiment. Five dose levels of each test oil were applied daily to the skin of C3Hf/He mice for two weeks. At the end of the two week treatment period all mice were humanely sacrificed and histological sections of the skin were examined for inflammatory changes. Representative tissues from major organ systems were also examined for signs of systemic toxicity. Neither of the reference petroleum crude oils caused severe inflammation, while both shale oils caused marked inflammation accompanied by ulceration at the higher dose levels.

• Research Organization: Los Alamos Scientific Lab., NM (USA)
• DOE Contract Number: W-7405-ENG-36
• OSTI ID: 6135411
• Report Number(s): LA-7967-MS
• Country of Publication: United States
• Language: English

Related Subjects

02 PETROLEUM
020600 -- Petroleum-- Health & Safety
04 OIL SHALES AND TAR SANDS
040700 -- Oil Shales & Tar Sands-- Health & Safety
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOCHEMICAL REACTION KINETICS
BODY
CARCINOGENS
DISEASES
ENERGY SOURCES
FOSSIL FUELS
FUELS
INFLAMMATION
KINETICS
MAMMALS
MICE
MINERAL OILS
MORPHOLOGICAL CHANGES
OILS
ORGANIC COMPOUNDS
ORGANS
OTHER ORGANIC COMPOUNDS
PATHOLOGICAL CHANGES
PETROLEUM
REACTION KINETICS
RODENTS
SHALE OIL
SKIN
SKIN ABSORPTION
SYNTHETIC FUELS
SYNTHETIC PETROLEUM
TOXICITY
ULCERS
UPTAKE
VERTEBRATES