Renal toxicity of middle distillates of shale oil and petroleum in mice
Journal Article
·
· Toxicol. Appl. Pharmacol.; (United States)
The tumorigenic potential of middle distillates (JP5, JP8, and diesel fuel marine) of shale oil and petroleum was studied by chronic dermal application on mice. These materials were applied to the backs of young C3Hf/Bd mice three times weekly for 60 weeks. After 30 weeks of treatment, increased water consumption was observed in all test groups, and increased urine production was seen in many of these groups. Two mice that died in the last week of treatment had severe renal lesions. At the end of the experiment an additional 42 of 336 mice had similar renal lesions. Macroscopically, the characteristic renal lesion consisted of pale, irregular, depressed foci that appeared cuneiform when the kidney was bisected. These lesions appeared to be old infarcts, but microscopically they lacked the usual features of infarction, such as necrosis, hemorrhage, inflammation, and fibrosis. The nature of the lesions suggests that the renal toxicity of these materials is mediated through some type of vascular phenomenon resulting in chronic ischemia. There appeared to be little difference between shale and petroleum-derived distillates.
- Research Organization:
- Oak Ridge National Lab., TN
- DOE Contract Number:
- W-7405-ENG-26
- OSTI ID:
- 6081424
- Journal Information:
- Toxicol. Appl. Pharmacol.; (United States), Journal Name: Toxicol. Appl. Pharmacol.; (United States) Vol. 65; ISSN TXAPA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
02 PETROLEUM
020600* -- Petroleum-- Health & Safety
04 OIL SHALES AND TAR SANDS
040700 -- Oil Shales & Tar Sands-- Health & Safety
560305 -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY
BODY FLUIDS
CARDIOVASCULAR DISEASES
DISEASES
DISTILLATES
ENERGY SOURCES
FOSSIL FUELS
FUELS
HISTOLOGY
ISCHEMIA
KIDNEYS
MAMMALS
MATERIALS
MICE
MINERAL OILS
OILS
ORGANIC COMPOUNDS
ORGANS
OTHER ORGANIC COMPOUNDS
PATHOLOGICAL CHANGES
PETROLEUM PRODUCTS
RODENTS
SHALE OIL
TOXICITY
URINE
VASCULAR DISEASES
VERTEBRATES
WASTES
020600* -- Petroleum-- Health & Safety
04 OIL SHALES AND TAR SANDS
040700 -- Oil Shales & Tar Sands-- Health & Safety
560305 -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY
BODY FLUIDS
CARDIOVASCULAR DISEASES
DISEASES
DISTILLATES
ENERGY SOURCES
FOSSIL FUELS
FUELS
HISTOLOGY
ISCHEMIA
KIDNEYS
MAMMALS
MATERIALS
MICE
MINERAL OILS
OILS
ORGANIC COMPOUNDS
ORGANS
OTHER ORGANIC COMPOUNDS
PATHOLOGICAL CHANGES
PETROLEUM PRODUCTS
RODENTS
SHALE OIL
TOXICITY
URINE
VASCULAR DISEASES
VERTEBRATES
WASTES