Solvent-refined-coal (SRC) process: health programs. Final report of subcontract No. 12, industrial hygiene, clinical and toxicological programs. Interim report No. 75, August 1, 1980-March 31, 1982. [Oral, dermal, eye and inhalation (distillate only) administration]

Technical Report · Sat May 01 04:00:00 EDT 1982

OSTI ID:5433393

This final report summarizes the acute toxicity studies conducted on SRC-II materials as part of the toxicological program under the Solvent-Refined-Coal (SRC) Process Contract for the period August 1, 1980 through March 31, 1982. Three materials were studied in this part of the program: coal slurry, stripper tower bottoms, and middle distillate. The materials were evaluated for: toxicity when administered orally in a single dose to rats; toxicity when administered dermally in a single dose to the intact and abraded skin of rabbits; the eye irritation potential when instilled into the rabbit eye; and, the sensitization potential when applied to the intact skin of the guinea pig. In addition, the middle distillate was also evaluated for aspiration hazard and toxicity when administered once into the oral cavity of rats, and the acute inhalation toxicity of a vapor/aerosol mixture when administered to rats by whole body inhalation exposure for four hours. All studies were performed according to approved detailed protocols, FDA Good Laboratory Practice Regulations, and quality assurance audits. Based on the results of these studies, it has been concluded that the coal slurry is not acutely toxic by either the oral or dermal route, must be classified as a mild eye irritant, and may on occasion cause slight dermal sensitization. The stripper tower bottoms is not acutely toxic by either the oral or dermal route, is not an eye irritant, and may on occasion cause slight dermal sensitization. Middle distillate appears to show moderate toxicity by the acute oral route but no acute dermal toxicity, must be classified as a mild eye irritant and may on occasion cause slight dermal sensitization. Middle distillate was also deemed to be an aspiration hazard as would be expected and showed moderate toxicity by the acute inhalation route.

• Research Organization: Pittsburg and Midway Coal Mining Co., Englewood, CO (USA); International Research and Development Corp., Mattawan, MI (USA)
• DOE Contract Number: AC05-76ET10104
• OSTI ID: 5433393
• Report Number(s): DOE/ET/10104-56; ON: DE82013883
• Country of Publication: United States
• Language: English

Related Subjects

01 COAL, LIGNITE, AND PEAT
010405 -- Coal
Lignite
& Peat-- Hydrogenation & Liquefaction
016000* -- Coal
Lignite
& Peat-- Health & Safety
560305 -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSORPTION
ANIMALS
BODY
BODY AREAS
CARBONACEOUS MATERIALS
COAL
COAL LIQUEFACTION
COAL LIQUIDS
DATA
DISPERSIONS
DISTILLATES
ENERGY SOURCES
EXPERIMENTAL DATA
EYES
FACE
FLUIDS
FOSSIL FUELS
FUEL SLURRIES
FUELS
GUINEA PIGS
HAZARDS
HEAD
HEALTH HAZARDS
INDUSTRIAL MEDICINE
INFORMATION
INHALATION
INTAKE
LIQUEFACTION
LIQUIDS
MAMMALS
MATERIALS
MEDICINE
MIXTURES
NUMERICAL DATA
ORAL ADMINISTRATION
ORGANIC SOLVENTS
ORGANS
RABBITS
RATS
RESIDUES
RODENTS
SENSE ORGANS
SKIN ABSORPTION
SLURRIES
SOLVENTS
SRC-II PROCESS
SUSPENSIONS
THERMOCHEMICAL PROCESSES
TOXICITY
UPTAKE
VERTEBRATES