Effect of pelvic irradiation on the absorption of bile acids
The pathophysiology of radiation-induced diarrhea was evaluated in 17 patients undergoing pelvic irradiation for gynecological malignancies. The glycine conjugates of cholic acid (GC) and chenodeoxycholic acid (GCDC) were measured in serum by radioimmunoassay. Fasting and 2 hour post prandial (pp) determinations were performed prior to and in the fifth week of radiotherapy. The pre-treatment fasting and 2 hour pp GC levels were 0.20 +- 0.29 (mean +- SD) and 0.48 +- 0.47 ..mu..M. In the fifth week the fasting and 2 hour pp GC levels were 0.16 +- 0.23 and 0.25 +- 0.27 ..mu..M. The first week fasting and 2 hour pp GCDC levels were 0.32 +- 0.47 and 0.80 +- 0.83 ..mu..M: in the fifth week they were 0.10 +- 0.06 and 0.33 +- 0.27 ..mu..M. The differences between the first and the fifth week post prandial increases in serum GC and GCDC levels were significant (P<0.02). The reduced post prandial increases in serum GC and GCDC in the fifth week of radiotherapy occurred at a time when the patients' daily stool frequencies were significantly increased (P<0.01). The data suggest that a cholerrheic enteropathy is the major determinant in the pathophysiology of radiation-induced diarrhea.
- Research Organization:
- Pennsylvania State Univ., Hershey
- OSTI ID:
- 6818752
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 5:7
- Country of Publication:
- United States
- Language:
- English
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BILE ACIDS
INTESTINAL ABSORPTION
DIARRHEA
RADIOINDUCTION
SMALL INTESTINE
BIOLOGICAL RADIATION EFFECTS
FRACTIONATED IRRADIATION
LABELLED COMPOUNDS
LOCAL IRRADIATION
PATIENTS
PELVIS
RADIATION DOSES
RADIOIMMUNOASSAY
RADIOTHERAPY
SIDE EFFECTS
TRITIUM
X RADIATION
ABSORPTION
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BODY
BODY AREAS
CARBOXYLIC ACIDS
DIGESTIVE SYSTEM
DOSES
ELECTROMAGNETIC RADIATION
GASTROINTESTINAL TRACT
HYDROGEN ISOTOPES
HYDROXY COMPOUNDS
INTESTINES
IONIZING RADIATIONS
IRRADIATION
ISOTOPE APPLICATIONS
ISOTOPES
LIGHT NUCLEI
MEDICINE
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
RADIATION EFFECTS
RADIATIONS
RADIOASSAY
RADIOISOTOPES
RADIOLOGY
STEROIDS
STEROLS
SYMPTOMS
THERAPY
TRACER TECHNIQUES
UPTAKE
YEARS LIVING RADIOISOTOPES
550603* - Medicine- External Radiation in Therapy- (1980-)
560151 - Radiation Effects on Animals- Man