Absence of bile acid malabsorption as a late effect of pelvic irradiation
The pathophysiology of chronic radiation-induced diarrhea was evaluated in 28 patients who had undergone pelvic irradiation for gynecologic neoplasms 2 to 7 years previously. Twenty-seven patients undergoing radiotherapy with techniques that did not require abdominal or pelvic irradiation served as controls. The glycine conjugates of cholic acid (GC) were measured in serum by radioimmunoassay. Fasting and 2 hr. pp GC levels for the pelvic irradiated patients were 11.0 +/- 11.1 (mean +/- SD) and 24.8 +/- 17.3 micrograms/dl. Fasting and 2 hr. pp GC levels for controls were 12.6 +/- 7.4 and 28.0 +/- 14.7. There were no significant differences in the post-prandial increases in serum GC between pelvic irradiated patients and controls (p = .23, Type II error probability = .13). There was also no significant difference in the 2 hr. pp and fasting GC ratio (p = .39). There was significant difference between the stool frequency (p less than .01) and the prevalence of diarrhea (p less than .02) between pelvic irradiated patients and controls. The data suggest that bile acid malabsorption due to ileal dysfunction is not an inevitable late complication of pelvic irradiation and is not the major determinant in the pathophysiology of chronic radiation-induced diarrhea.
- Research Organization:
- Pennsylvania State Univ., Hershey
- OSTI ID:
- 6934140
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 9; ISSN IOBPD
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560151* -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSORPTION
BILE ACIDS
BODY
BODY AREAS
CARBOXYLIC ACIDS
CHOLIC ACID
CHRONIC EXPOSURE
CHRONIC IRRADIATION
DIARRHEA
DISEASES
HYDROXY COMPOUNDS
IMMUNOASSAY
IMMUNOLOGY
INTESTINAL ABSORPTION
IRRADIATION
ISOTOPE APPLICATIONS
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
ORGANIC ACIDS
ORGANIC COMPOUNDS
PATIENTS
PELVIS
RADIOASSAY
RADIOIMMUNOASSAY
RADIOIMMUNOLOGY
RADIOINDUCTION
RADIOLOGY
RADIOTHERAPY
SIDE EFFECTS
STEROIDS
STEROLS
SYMPTOMS
THERAPY
TRACER TECHNIQUES
UPTAKE
UROGENITAL SYSTEM DISEASES