Effect of pelvic irradiation on the absorption of bile acids
The pathophysiology of radiation-induced diarrhea was evaluated in 17 patients undergoing pelvic irradiation for gynecological malignancies. The glycine conjugates of cholic acid (GC) and chenodeoxycholic acid (GCDC) were measured in serum by radioimmunoassay. Fasting and 2 hour post prandial (pp) determinations were performed prior to and in the fifth week of radiotherapy. The pre-treatment fasting and 2 hour pp GC levels were 0.20 +- 0.29 (mean +- SD) and 0.48 +- 0.47 ..mu..M. In the fifth week the fasting and 2 hour pp GC levels were 0.16 +- 0.23 and 0.25 +- 0.27 ..mu..M. The first week fasting and 2 hour pp GCDC levels were 0.32 +- 0.47 and 0.80 +- 0.83 ..mu..M: in the fifth week they were 0.10 +- 0.06 and 0.33 +- 0.27 ..mu..M. The differences between the first and the fifth week post prandial increases in serum GC and GCDC levels were significant (P<0.02). The reduced post prandial increases in serum GC and GCDC in the fifth week of radiotherapy occurred at a time when the patients' daily stool frequencies were significantly increased (P<0.01). The data suggest that a cholerrheic enteropathy is the major determinant in the pathophysiology of radiation-induced diarrhea.
- Research Organization:
- Pennsylvania State Univ., Hershey
- OSTI ID:
- 6818752
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 5:7; ISSN IOBPD
- Country of Publication:
- United States
- Language:
- English
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560151 -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSORPTION
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BILE ACIDS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY AREAS
CARBOXYLIC ACIDS
DIARRHEA
DIGESTIVE SYSTEM
DOSES
ELECTROMAGNETIC RADIATION
FRACTIONATED IRRADIATION
GASTROINTESTINAL TRACT
HYDROGEN ISOTOPES
HYDROXY COMPOUNDS
INTESTINAL ABSORPTION
INTESTINES
IONIZING RADIATIONS
IRRADIATION
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
LOCAL IRRADIATION
MEDICINE
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PATIENTS
PELVIS
RADIATION DOSES
RADIATION EFFECTS
RADIATIONS
RADIOASSAY
RADIOIMMUNOASSAY
RADIOINDUCTION
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
SIDE EFFECTS
SMALL INTESTINE
STEROIDS
STEROLS
SYMPTOMS
THERAPY
TRACER TECHNIQUES
TRITIUM
UPTAKE
X RADIATION
YEARS LIVING RADIOISOTOPES