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Effect of pelvic irradiation of ileal function. [/sup 14/C tracer technique]

Conference · · Radiology; (United States)
OSTI ID:7312070
; ;

Thirty-three patients with gynecological neoplasms undergoing radiotherapy to the pelvis had cholyl(1-/sup 14/C)glycine breath tests to assess ileal function. Breath tests were performed on each patient in the first and fifth weeks of treatment and 19 of the patients had a third test three months post-treatment. In the first test, 29.9 +- 16.8 percent (mean +- SD) of the administered dose was excreted in breath /sup 14/C in 24 hours. This rose to 47.3 +- 15.9 percent (t = 6.08; p less than .001) in the fifth week and fell to 36.3 +- 16 percent (t = 2.29; p less than .05) at three months post-treatment. Eight patients had breath tests performed one year post-treatment and the test percentages were 32.7 +- 7.8 percent (t = 1.19; p greater than .10). The increase in /sup 14/CO/sub 2/ excretion in the fifth week of treatment occurred at a time when most patients were having diarrhea. The data suggest that bile acid malabsorption due to ileal dysfunction may be a factor in radiation-induced diarrhea which occurs in nearly all patients during pelvic irradiation.

Research Organization:
Pennsylvania State Univ., Hershey
OSTI ID:
7312070
Journal Information:
Radiology; (United States), Journal Name: Radiology; (United States) Vol. 124:1; ISSN RADLA
Country of Publication:
United States
Language:
English

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Related Subjects

560151* -- Radiation Effects on Animals-- Man
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
BODY AREAS
BREATH
CARBON 14
CARBON ISOTOPES
DIARRHEA
DIGESTIVE SYSTEM
DISEASES
EVEN-EVEN NUCLEI
GASTROINTESTINAL TRACT
INTESTINES
ISOTOPE APPLICATIONS
ISOTOPES
LIGHT NUCLEI
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
ORGANS
PATIENTS
PELVIS
RADIOINDUCTION
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
SIDE EFFECTS
SMALL INTESTINE
SYMPTOMS
THERAPY
TRACER TECHNIQUES
YEARS LIVING RADIOISOTOPES