/sup 14/C-lactose breath tests during pelvic radiotherapy: the effect of the amount of small bowel irradiated
Thirty patients who were undergoing pelvic radiotherapy had /sup 14/C-lactose breath tests performed in the first and fifth weeks of treatment. In Group I (21 patients), a significant portion of the small intestine was irradiated, and in Group II (9 patients), only a small portion of the small intestine was irradiated. In Group I, the average reductions in the excretion of ingested /sup 14/C between the first- and fifth-week tests were 41.5% at 1/2 hour postingestion (p<0.05), and 21.8% at 1 hour postingestion (p<0.05). In Group II, the prercentage reduction were 11.8% and 3.7% at 1/2 and 1 hour, respectively (p>0.05). The data suggest that lactose malabsorption is a factor in the etiology of the nausea, vomiting, and diarrhea experienced by patients who are undergoing pelvic radiotherapy, and that the amount of bowel included in the treatment volume significantly influences the degree of malabsorption.
- Research Organization:
- M.S. Hershey Medical Center, Hershey, PA
- OSTI ID:
- 5576863
- Journal Information:
- Radiology; (United States), Journal Name: Radiology; (United States) Vol. 142:2; ISSN RADLA
- Country of Publication:
- United States
- Language:
- English
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62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSORPTION
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CARBOHYDRATES
CARBON 14 COMPOUNDS
DIGESTIVE SYSTEM
DISACCHARIDES
DISEASES
EXTERNAL IRRADIATION
GASTROINTESTINAL TRACT
INTESTINAL ABSORPTION
INTESTINES
IRRADIATION
LABELLED COMPOUNDS
LACTOSE
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
OLIGOSACCHARIDES
ORGANIC COMPOUNDS
ORGANS
PARTIAL BODY IRRADIATION
PATIENTS
RADIATION EFFECTS
RADIATION SYNDROME
RADIOLOGY
RADIOTHERAPY
SACCHARIDES
SIDE EFFECTS
SMALL INTESTINE
THERAPY
UPTAKE