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Prophylactic ibuprofed administration during pelvic irradiation

Journal Article · · Int. J. Radiat. Oncol., Biol. Phys.; (United States)
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Thirty-five patients who were to begin pelvic irradiation for malignant disease were randomized to receive ibuprofen 400 mg P.O. q.i.d. during their radiotherapy or standard therapy for radiation-induced gastrointestinal symptoms. Seventeen of 19 patients in the ibuprofen group completed the protocol. There was no significant difference in the daily stool frequency between the ibuprofen and control patients during the 5 to 6 week course of pelvic irradiation; the incidence and severity of diarrhea was the same. There was no significant difference in the incidence of nausea reported by the patients but the severity of nausea was less in the ibuprofen group; none of the 17 patients in the ibuprofen group reported vomiting at any time, whereas, 27% of the patients in the control group reported vomiting. The difference was statistically significant (p < 0.05). The data suggest that prophylactic ibuprofen administration may be beneficial in reducing the severity of nausea and preventing radiation-induced vomiting in patients who receive pelvic irradiation.

Research Organization:
Pennsylvania State Univ., Hershey, PA
OSTI ID:
5482900
Journal Information:
Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 5:11-12; ISSN IOBPD
Country of Publication:
United States
Language:
English

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Related Subjects

550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560151* -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BODY
BODY AREAS
CARCINOMAS
DATA
DATA COMPILATION
DATA FORMS
DIARRHEA
DISEASES
ELECTROMAGNETIC RADIATION
INFORMATION
IONIZING RADIATIONS
MEDICINE
NAUSEA
NEOPLASMS
NUCLEAR MEDICINE
NUMERICAL DATA
PATIENTS
PELVIS
PREVENTIVE MEDICINE
RADIATION SYNDROME
RADIATIONS
RADIOLOGY
RADIOTHERAPY
SIDE EFFECTS
SYMPTOMS
TABLES
THERAPY
VOMITING
X RADIATION