Thermal-ionization isotope-dilution mass spectrometry as a definitive method for determination of potassium in serum

Journal Article · Tue Jun 01 04:00:00 EDT 1982 · Clin. Chem. (Winston-Salem, N.C.); (United States)

OSTI ID:6817189

Gramlich, J W; Machlan, L A; Brletic, K A; Kelly, W R

Thermal-ionization isotope-dilution mass spectrometry is a highly precise and accurate method for the determination of potassium concentrations in serum. Although not suited for routine use because of the time and expense required, the technique provides an extremely valuable tool for the characterization of reference materials and for evaluating other analytical methods. The technique has recently been used to determine the concentration of potassium in a human serum standard, NBS Standard Reference Material 909. Seven vials of the serum were chemically processed and then analyzed by two spectroscopists independently, using different mass spectrometers. The results confirm previous work that indicates that a precision of 0.1% relative can be routinely achieved. The systematic errors in the method have been thoroughly evaluated. When the precise results are thus corrected, they are essentially bias free and hence definitive.

• Research Organization: National Bureau of Standards, Washington, DC
• OSTI ID: 6817189
• Journal Information: Clin. Chem. (Winston-Salem, N.C.); (United States), Journal Name: Clin. Chem. (Winston-Salem, N.C.); (United States) Vol. 28:6; ISSN CLCHA
• Country of Publication: United States
• Language: English

Related Subjects

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
400102 -- Chemical & Spectral Procedures
550200* -- Biochemistry
59 BASIC BIOLOGICAL SCIENCES
ACCURACY
ALKALI METALS
BLOOD SERUM
CHEMICAL ANALYSIS
COMPARATIVE EVALUATIONS
ELEMENTS
ERRORS
IONIZATION
ISOTOPE APPLICATIONS
ISOTOPE DILUTION
LYOPHILIZATION
MASS SPECTROSCOPY
METALS
POTASSIUM
QUANTITATIVE CHEMICAL ANALYSIS
SODIUM
SPECTROSCOPY
TRACER TECHNIQUES