Determination of iron in serum and water by resonance ionization isotope dilution mass spectrometry
Resonance ionization mass spectrometry has been used in conjunction with isotope dilution to determine the iron content of SRM 909 (Human Serum) and SRM 1643b (Trace Elements in Water). Iron was thermally vaporized from a filament at 1250 K. A one-wavelength, two-photon ionization scheme was employed utilizing UV light at 283.6 nm provided by a Nd:YAG pumped dye laser with frequency doubling. The linearity of the detection system was verified by the determination of the /sup 57/Fe//sup 56/Fe ratios in a set of gravimetrically prepared isotopic calibration mixes. The precision and accuracy of the measurements were typically 2-3%. The mass spectrometric loading blank is presently the limiting source of error. The concentration and uncertainty (95% confidence limits) of Fe in SRM 909 are 1.94 +/- 0.29 ..mu..g/g; in SRM 1643b they are 99.2 +/- 8.3 ng/g.
- Research Organization:
- National Bureau of Standards, Gaithersburg, MD
- OSTI ID:
- 5566256
- Journal Information:
- Anal. Chem.; (United States), Vol. 56:12
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
ORGANIC
PHYSICAL AND ANALYTICAL CHEMISTRY
59 BASIC BIOLOGICAL SCIENCES
99 GENERAL AND MISCELLANEOUS//MATHEMATICS, COMPUTING, AND INFORMATION SCIENCE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BLOOD SERUM
QUANTITATIVE CHEMICAL ANALYSIS
IRON
RESONANCE IONIZATION MASS SPECTROSCOPY
WATER
DYE LASERS
EXPERIMENTAL DATA
FREQUENCY CONVERTERS
ISOTOPE DILUTION
NEODYMIUM LASERS
TRACE AMOUNTS
ULTRAVIOLET RADIATION
VERY HIGH TEMPERATURE
CHEMICAL ANALYSIS
DATA
ELECTROMAGNETIC RADIATION
ELEMENTS
HYDROGEN COMPOUNDS
INFORMATION
ISOTOPE APPLICATIONS
LASERS
LIQUID LASERS
MASS SPECTROSCOPY
METALS
NUMERICAL DATA
OXYGEN COMPOUNDS
RADIATIONS
SOLID STATE LASERS
SPECTROSCOPY
TRACER TECHNIQUES
TRANSITION ELEMENTS
400104* - Spectral Procedures- (-1987)
550500 - Metabolism
552000 - Public Health
560306 - Chemicals Metabolism & Toxicology- Man- (-1987)