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Clinical comparison of /sup 99m/Tc N,N'-bis(mercaptoacetamido)ethylenediamine and (/sup 131/I)ortho-iodohippurate for evaluation of renal tubular function: concise communication

Journal Article · · J. Nucl. Med.; (United States)
OSTI ID:6816787
; ; ; ; ; ;
Recent experiments in normal animals have shown that /sup 99m/Tc N,N'-bis(mercaptoacetamido)ethylenediamine (/sup 99m/Tc DADS) is a potential technetium-99m-labeled replacement for (/sup 131/I)ortho-iodohippurate. We compared the two agents in eleven patients with renal transplants (serum creatinine range: 0.9--5.7 mg/dl). Digital and analog images were recorded for 30 min and after voiding. The results indicate that the relative extraction efficiency index of /sup 99m/Tc DADS is 76% +/- 3 (mean +/- s.e.m.), that the leading-edge parenchymal transit time of /sup 99m/Tc DADS is 137% +/- 6, and that the percentage of injected /sup 99m/Tc DADS in the bladder at 30 min is 25% +/- 4 of that of /sup 131/I Hipp (all p less than 0.05). Forty percent of patients showed some hepatobiliary excretion of /sup 99m/Tc DADS. We conclude that the biologic properties of /sup 99m/Tc DADS are inferior to those of /sup 131/I Hipp and that analogs of /sup 99m/Tc DADS should be evaluated in an attempt to find a more suitable technetium-99m-labeled replacement for /sup 131/I Hipp.
Research Organization:
University of Colorado Health Sciences Center, Denver
OSTI ID:
6816787
Journal Information:
J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 23:5; ISSN JNMEA
Country of Publication:
United States
Language:
English

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Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
COMPARATIVE EVALUATIONS
CONTRAST MEDIA
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DRUGS
HIPPURAN
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IODINE 131
IODINE ISOTOPES
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KIDNEYS
LABELLED COMPOUNDS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PATIENTS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOPHARMACEUTICALS
SCINTISCANNING
TECHNETIUM 99
TECHNETIUM ISOTOPES
TRANSPLANTS
USES
YEARS LIVING RADIOISOTOPES