Clinical evaluation of Tc-99m N,N'-bis(mercaptoacetyl)-2,3-diaminopropanoate as a replacement for I-131 hippurate: concise communication

Journal Article · Sun Jan 01 04:00:00 EST 1984 · J. Nucl. Med.; (United States)

OSTI ID:5442520

Kingensmith, III, W C; Fritzberg, A R; Spitzer, V M; Johnson, D L; Kuni, C C; Williamson, M R; Washer, G; Weil, R III

A clinical comparison of Tc-99m N,N'-bis(mercaptoacetyl)-2,3-diaminopropanoate (Component A) (Tc-99m CO/sub 2/-DADS-A) and I-131 hippurate was conducted in a series of five normal volunteers and 18 patients. Each subject was studied in one session with Tc-99m CO/sub 2/-DADS-A and I-131-hippurate; digital and analog images were recorded for 30 min and after voiding. In the normal volunteers, digital images with Tc-99m CO/sub 2/-DADS-A gave a kidney-to-background ratio at 3 min that was greater relative to I-131 hippurate, a leading-edge parenchymal transit time that was similar to I-131 hippurate, and a percent injected dose in the urine at 30 min that was slightly less than I-131 hippurate (p<0.05). In patients (serum creatinine 1.0 to 14.3 mg/dl), deceasing renal function impaired excretion of Tc-99m CO/sub 2/-DADS-A more than that of I-131 hippurate (p < 0.01). In analog images, Tc-99mCO/sub 2/-DADS-A always gave superior spatial resolution. No evidence of hepatobiliary excretion was detected with either radiopharmaceutical. The authors conclude that Tc-99m CO/sub 2/-DADS-A and similar compounds should be pursued as possible replacements for I-131 hippurate

• Research Organization: Univ. of Colorado Health Sciences Center, Denver, CO
• OSTI ID: 5442520
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 25:1; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
COMPARATIVE EVALUATIONS
CONTRAST MEDIA
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DRUGS
DYNAMIC FUNCTION STUDIES
HIPPURAN
HOURS LIVING RADIOISOTOPES
HYDROXY COMPOUNDS
INTERMEDIATE MASS NUCLEI
IODINE 131
IODINE ISOTOPES
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KIDNEYS
LABELLED COMPOUNDS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PATIENTS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOPHARMACEUTICALS
RESOLUTION
SCINTISCANNING
SPATIAL RESOLUTION
TECHNETIUM 99
TECHNETIUM ISOTOPES
YEARS LIVING RADIOISOTOPES