Synthesis and biological evaluation of /sup 99m/Tc N,N'-bis(mercaptoacetyl)-2,3-diaminopropanoate: a potential replacement for (/sup 131/I)o-iodohippurate

Journal Article · Thu Jul 01 04:00:00 EDT 1982 · J. Nucl. Med.; (United States)

OSTI ID:6718395

Fritzberg, A R; Kuni, C C; Klingensmith, W C; Stevens, J; Whitney, W P

A new technetium-chelating agent based on amide and mercaptide donor groups, N,N'-bis(mercaptoacetyl)-2,3-diaminopropanoate, was synthesized as an analog of previously described N,N'-bis(mercaptoacetyl)ethylenediamine (DADS). Complexation of /sup 99m/Tc with the new chelating group resulted in two components that were separable by high-performance liquid chromatography. The component that eluted first demonstrated high specificity for renal excretion, with over 90% in the urine of rabbits at 35 min, 87% in the urine of mice at 2 hr, and 1.6% or less in the intestines of mice. Excretion was rapid, with the first component equaling or exceeding (/sup 131/I)o-iodohippurate in the urine of rabbits at all times. The second or latter component demonstrated comparable specificity but slightly slower renal excretion kinetics. Clinical trials with the first component are probably warranted.

• Research Organization: University of Colorado Health Sciences Center, Denver
• OSTI ID: 6718395
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 23:7; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
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551001 -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOCHEMICAL REACTION KINETICS
CHEMICAL ANALYSIS
CHEMICAL PREPARATION
CHROMATOGRAPHY
COMPARATIVE EVALUATIONS
DAYS LIVING RADIOISOTOPES
DISTRIBUTION
FUNCTIONS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IODINE 131
IODINE ISOTOPES
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KINETICS
LABELLED COMPOUNDS
LABORATORY ANIMALS
LIQUID COLUMN CHROMATOGRAPHY
NUCLEI
ODD-EVEN NUCLEI
QUANTITATIVE CHEMICAL ANALYSIS
RADIOISOTOPES
RADIONUCLIDE KINETICS
REACTION KINETICS
RETENTION FUNCTIONS
SEPARATION PROCESSES
SYNTHESIS
TECHNETIUM 99
TECHNETIUM ISOTOPES
TISSUE DISTRIBUTION
YEARS LIVING RADIOISOTOPES