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Critical organ concentration of cadmium in occupationally-exposed workers

Conference ·
OSTI ID:6805914
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This report describes the present Brookhaven facility for in vivo measurements of cadmium in man and provides a comparison with other portable systems. The cadmium detection limits are 2.2 mg in the kidney and 1.5 ppM in the liver for the Brookhaven system. In a recent field study, the cadmium content of the left kidney and concentration in the liver were measured in 82 occupationally exposed workers and 10 control subjects. Organ content ranged up to 57 mg in the kidney and up to 120 ppM in the liver for the industrial group. By contrast, the values for the control group ranged from 0.4 to 11.8 mg for the kidney and 0.7 to 7.9 ppM for the liver. The geometric means were 3.7 mg for the kidney and 2.7 ppM for the liver in the control group. When the data were analyzed to provide an estimate of the critical concentration for the kidney, a range of 300 to 400 ..mu..g/g for the renal cortex was calculated. The corresponding cadmium concentrations in the liver and urine were 30 to 42 ppM (liver) and 22 to 28 ..mu..g/g creatinine (urine), respectively. Blood and urine levels of cadmium and ..beta../sub 2/-microgloubin were also evaluated as possible biological indicators of organ content.
Research Organization:
Brookhaven National Lab., Upton, NY (USA)
DOE Contract Number:
AC02-76CH00016
OSTI ID:
6805914
Report Number(s):
BNL-29066; CONF-810238-2
Country of Publication:
United States
Language:
English

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Related Subjects

560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTIVATION ANALYSIS
BARYON REACTIONS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BLOOD SERUM
BODY
BODY BURDEN
BODY FLUIDS
CADMIUM
CHEMICAL ANALYSIS
CRITICAL ORGANS
DIGESTIVE SYSTEM
ELEMENTS
GLANDS
HADRON REACTIONS
KIDNEYS
LIVER
MATERIALS
METALS
MONITORING
NEUTRON REACTIONS
NUCLEAR REACTIONS
NUCLEON REACTIONS
OCCUPATIONAL DISEASES
ORGANS
QUANTITATIVE CHEMICAL ANALYSIS
TOXICITY
URINE
WASTES