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In vivo measurement of cadmium in an occupationally-exposed population

Conference ·
OSTI ID:5260414
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Exposure to cadmium is recognized as a potentially serious health problem. A number of clinical abnormalities have been observed in workers occupationally exposed to cadmium. Therefore, it is essential that accurate data on body burdens be available in order to formulate dose-response relationships in man. The present Brookhaven facility for in vivo measurements of cadmium in man is described, and recent results from a field study to a cadmium production plant are reported. The cadmium content of the left kidney and concentration in the liver were measured by prompt-gamma neutron activation analysis in 82 occupationally exposed workers and 10 control subjects. Organ content ranged up to 57 mg in the kidney and up to 120 ppM in the liver for the industrial group. By contrast, the values for the control group ranged from 0.4 to 11.8 mg for the kidney and 0.7 to 7.9 ppM for the liver. The geometric means were 3.7 mg for the kidney and 2.7 ppM for the liver in the control group. When the data were analyzed to provide an estimate of the critical concentration for the kidney, a range of 300 to 400 ..mu..g/g for the renal cortex was calculated. These results are compared with the available data in the literature.
Research Organization:
Brookhaven National Lab., Upton, NY (USA)
Sponsoring Organization:
USDOE
DOE Contract Number:
AC02-76CH00016
OSTI ID:
5260414
Report Number(s):
BNL-27859; CONF-800433-5
Country of Publication:
United States
Language:
English

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Related Subjects

560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTIVATION ANALYSIS
BARYON REACTIONS
BIOLOGICAL ACCUMULATION
BIOLOGICAL EFFECTS
BODY
BODY BURDEN
CADMIUM
CHEMICAL ANALYSIS
DIGESTIVE SYSTEM
ELEMENTS
GLANDS
HADRON REACTIONS
IN VIVO
INDUSTRIAL MEDICINE
KIDNEYS
LIVER
MEDICINE
METALS
NEUTRON REACTIONS
NUCLEAR REACTIONS
NUCLEON REACTIONS
ORGANS
PERSONNEL
TRACE AMOUNTS