In vivo measurement of critical level of kidney cadmium: dose effect studies in cadmium smelter workers

Journal Article · Tue Jan 01 04:00:00 EST 1980 · Am. J. Ind. Med.; (United States)

DOI:https://doi.org/10.1002/ajim.4700010310· OSTI ID:5569474

Ellis, K J ^[1]; Morgan, W D; Zanzi, I; Yasumura, S; Vartsky, D; Cohn, S H

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1. Brookhaven National Lab., Upton, NY

In vivo measurements of kidney and liver cadmium burdens were obtained in 82 industrially exposed workers and ten control subjects. Kidney cadmium levels ranged from 0.9 mg to 57 mg, and liver concentrations ranged from 0.8 ppM to 120 ppM for the industrial group. Comparison values for the control group were 0.4 mg to 11.8 mg for the kidney and 0.6 ppM to 7.9 ppM for the liver. A biphasic relationship between kidney Cd levels and liver Cd levels was observed. The kidney and liver Cd levels showed an increase until approximately a 40 ppM concentration was reached in the liver. Thereafter, the kidney levels decreased as the liver concentration continued to increase. The kidney cadmium level at which this change occurred was approximately 31 mg for the total kidney. Further estimates of the critical level, based on years of exposure and renal dysfunction (..beta../sub 2/-microglobulin, proteinuria), yielded estimates of 31 mg to 42 mg cadmium (300 to 400 ..mu..g/gm for the renal cortex).

• DOE Contract Number: AC02-76CH00016
• OSTI ID: 5569474
• Journal Information: Am. J. Ind. Med.; (United States), Journal Name: Am. J. Ind. Med.; (United States) Vol. 1; ISSN AJIMD
• Country of Publication: United States
• Language: English

Related Subjects

552000 -- Public Health
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
99 GENERAL AND MISCELLANEOUS
BODY
CADMIUM
DIGESTIVE SYSTEM
DISTRIBUTION
DOSE-RESPONSE RELATIONSHIPS
ELEMENTS
GLANDS
IN VIVO
KIDNEYS
LIVER
METABOLISM
METALS
OCCUPATIONAL SAFETY
ORGANS
PERSONNEL
PHYSIOLOGY
SAFETY
SMELTING
TISSUE DISTRIBUTION