Biological efficacy of a boronated porphyrin as measured in cell culture
Attempts to develop a boronated porphyrin analog have suffered from problems associated with toxicity, solubility and, upon occasion, lability of the boron tag. One compound synthesized by one of us (SBK), designated ''SBK-II'', has evidently overcome the above problems, providing therapeutic amounts of boron in animal tumor models (20-40 ..mu..g B/g tumor) with retention times in the order of weeks. As is well known, biological efficacy will depend upon distribution within (or without) the cell. In the experiments detailed here, biological efficacy has been evaluated in Hamster V-79 cells, irradiated at the thermal neutron beam at the Brookhaven Medical Research Reactor, using irradiation geometries and techniques as described in detail elsewhere. Cell survival curves obtained with 15 and 29 ..mu..g /sup 10/B per ml from H/sub 3//sup 10/BO/sub 3/ (''ambient'' conditions) were compared to a control (no boron) curve (data not shown). 2 refs., 3 figs., 1 tab.
- Research Organization:
- Brookhaven National Lab., Upton, NY (USA)
- DOE Contract Number:
- AC02-76CH00016
- OSTI ID:
- 6801975
- Report Number(s):
- BNL-41568; CONF-8705326-1; ON: DE88016578; TRN: 88-036035
- Resource Relation:
- Conference: 3. international symposium on neutron capture therapy, Bremen, F.R. Germany, 31 May 1987; Other Information: Portions of this document are illegible in microfiche products
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOLOGICAL LOCALIZATION
EVALUATION
BORON
TOXICITY
EXPERIMENTAL NEOPLASMS
NEUTRON CAPTURE THERAPY
BLOOD-BRAIN BARRIER
BRAIN
CELL CULTURES
CELL KILLING
HAMSTERS
PORPHYRINS
SOLUBILITY
ANIMALS
BODY
CARBOXYLIC ACIDS
CENTRAL NERVOUS SYSTEM
ELEMENTS
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
MAMMALS
MEDICINE
NERVOUS SYSTEM
NEUTRON THERAPY
NUCLEAR MEDICINE
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
RADIOLOGY
RADIOTHERAPY
RODENTS
SEMIMETALS
THERAPY
VERTEBRATES
550604* - Medicine- Unsealed Radionuclides in Therapy- (1980-)
560120 - Radiation Effects on Biochemicals
Cells
& Tissue Culture