Boronated porphyrins in NCT: Results with a new potent tumor localizer
Conference
·
OSTI ID:6172644
Several chemical methods are available for the solubilization of boronated porphyrins. We have previously reported the tumor localization of nido carboranyl porphyrins in which the icosahedral carborane cages have been opened to give B/sub 9/C/sub 2/ anions. One of these species has shown tumor boron levels of nearly 50 ..mu..g B/g when delivered by week-long subcutaneous infusions. We report here recent in vivo experiments with a new, highly water-soluble porphyrin based on the hematoporphyrin-type of compound in which aqueous solubility is achieved using the two propionic acid side chains of the ''natural'' porphyrin frame. 7 refs.
- Research Organization:
- Brookhaven National Lab., Upton, NY (USA)
- DOE Contract Number:
- AC02-76CH00016
- OSTI ID:
- 6172644
- Report Number(s):
- BNL-42522; CONF-8805150-11; ON: DE89010568
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550603* -- Medicine-- External Radiation in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
CARBOXYLIC ACIDS
DETECTION
DISEASES
EVALUATION
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
ISOTOPE APPLICATIONS
MEDICINE
NEOPLASMS
NEUTRON CAPTURE THERAPY
NEUTRON THERAPY
NUCLEAR MEDICINE
OPTIMIZATION
ORGANIC ACIDS
ORGANIC BORON COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PORPHYRINS
RADIOLOGY
RADIOTHERAPY
SOLUBILITY
STRUCTURE-ACTIVITY RELATIONSHIPS
THERAPY
TRACER TECHNIQUES
62 RADIOLOGY AND NUCLEAR MEDICINE
CARBOXYLIC ACIDS
DETECTION
DISEASES
EVALUATION
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
ISOTOPE APPLICATIONS
MEDICINE
NEOPLASMS
NEUTRON CAPTURE THERAPY
NEUTRON THERAPY
NUCLEAR MEDICINE
OPTIMIZATION
ORGANIC ACIDS
ORGANIC BORON COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PORPHYRINS
RADIOLOGY
RADIOTHERAPY
SOLUBILITY
STRUCTURE-ACTIVITY RELATIONSHIPS
THERAPY
TRACER TECHNIQUES