In vivo studies in NCT with a boronated porphyrin and tumor growth delay as an end point

Conference · Wed Jan 01 04:00:00 EST 1992

OSTI ID:6707890

Laster, B H ^[1]; Kahl, S B ^[2]; Warkentien, L; Bond, V P ^[3]

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1. Brookhaven National Lab., Upton, NY (United States) State Univ. of New York, Stony Brook, NY (United States). Dept. of Radiation Oncology
2. California Univ., San Francisco, CA (United States). Dept. of Pharmaceutical Chemistry
3. Brookhaven National Lab., Upton, NY (United States)

The robust carrying capacity of the porphyrin molecule and its propensity for localizing in tumor justified the synthesizing of a porphyrin labeled with boron for use in BNCT. However, problems associated with poor solubility impeded the utility of the molecule. Until BOPP was synthesized porphyrins were promising, but impractical. After in vitro experiments had demonstrated the biological efficacy of BOPP and had confirmed its intracellular localizing ability in vivo studies were carried out using mice. Irradiation of KHJJ murine mammary carcinoma to the TCD[sub 50] in a single fraction was precluded since this whole body dose is lethal. This problem was overcome by the use of radiation. BOPP was administered either as three 0.5 ml injections per day over two days or by continuous i.v. infusion, 2 ml per day over three days for a total dose of about 42 [mu]g [sup 10]B/gbw. Boron-10 distribution in the tumor at the time of irradiation was [approximately]20 [mu]g.

• Research Organization: Brookhaven National Lab., Upton, NY (United States)
• Sponsoring Organization: DOE; USDOE, Washington, DC (United States)
• DOE Contract Number: AC02-76CH00016
• OSTI ID: 6707890
• Report Number(s): BNL-48323; CONF-9209280--7; ON: DE93006647
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
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62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
BORON 10
BORON COMPOUNDS
BORON ISOTOPES
CARBOXYLIC ACIDS
CHEMICAL PREPARATION
DOSE RATES
DRUGS
EXPERIMENTAL NEOPLASMS
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
IN VIVO
ISOTOPES
LABELLED COMPOUNDS
LABELLING
LIGHT NUCLEI
MAMMALS
MEDICINE
MICE
NEUTRON CAPTURE THERAPY
NEUTRON THERAPY
NUCLEAR MEDICINE
NUCLEI
ODD-ODD NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PORPHYRINS
RADIOLOGY
RADIOPHARMACEUTICALS
RADIOTHERAPY
RODENTS
STABLE ISOTOPES
SYNTHESIS
THERAPY
VERTEBRATES