Comparison of spontaneous, UV-induced, and nitrosoguanidine-induced mutability to drug resistance in myxobacteria. [Polyangium luteum, Myxococcus xanthus]
Journal Article
·
· J. Bacteriol.; (United States)
OSTI ID:6801790
The uv survival curves of different strains of myxobacteria exhibited shoulders; in the case of Polyangium luteum, an unusual double shoulder appeared. Repair inhibitors like acriflavine, caffeine, and coumarin reduced the survival of uv-irradiated cells if the drugs were incorporated in the post-irradiation plating medium. The shoulders were reduced, but the final inactivation slopes were not affected by the repair inhibitors. Those strains that were resistant to uv were also more resistant to being killed by nitrosoguanidine. A variety of drug-resistant mutants occurred. The spontaneous mutation frequencies to drug resistance varied with the drug and the strain used. Drug-resistant mutants were inducible by uv irradiation and nitrosoguanidine. The uv mutability of Myxococcus xanthus was high compared to Cystobacter sp. However, the nitrosoguanidine mutability of M. xanthus was low compared to the other strains.
- Research Organization:
- Botanisches Institut der Universitaet (TH), Karlsruhe, Ger.
- OSTI ID:
- 6801790
- Journal Information:
- J. Bacteriol.; (United States), Journal Name: J. Bacteriol.; (United States) Vol. 135:3; ISSN JOBAA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560131* -- Radiation Effects on Microorganisms-- Basic Studies-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACRIDINES
ACRIFLAVINE
AMINES
AZINES
BACTERIA
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CAFFEINE
COUMARIN
DRUGS
ELECTROMAGNETIC RADIATION
ESTERS
FLAVINES
HETEROCYCLIC COMPOUNDS
LACTONES
MICROORGANISMS
MUTANTS
MUTATIONS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
PURINES
PYRANS
PYRIDINES
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
SURVIVAL CURVES
ULTRAVIOLET RADIATION
XANTHINES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACRIDINES
ACRIFLAVINE
AMINES
AZINES
BACTERIA
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CAFFEINE
COUMARIN
DRUGS
ELECTROMAGNETIC RADIATION
ESTERS
FLAVINES
HETEROCYCLIC COMPOUNDS
LACTONES
MICROORGANISMS
MUTANTS
MUTATIONS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
PURINES
PYRANS
PYRIDINES
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
SURVIVAL CURVES
ULTRAVIOLET RADIATION
XANTHINES